Neostigmine Impurity N4 CAS 3483-84-9
| CAS No. | 3483-84-9 |
| Molecular Formula | C9H13NO |
| Molecular Weight | 151.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Neostigmine Impurity N4 (C9H13NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Neostigmine Impurity N4 (CAS 3483-84-9) is a certified pharmaceutical impurity reference standard with the molecular formula C9H13NO and a molecular weight of 151.21 g/mol.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H13NO |
| Molecular Weight | 151.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Neostigmine Standards
- Neostigmine Impurity 24 (CAS 15799-79-8)
- Neostigmine impurity 40 (CAS CATO-C4X-204240)
- Neostigmine Impurity 21 (CAS 3958-86-9)
- Neostigmine impurity 32 (CAS 23040-64-4)
- Neostigmine EP Impurity B (CAS 99-07-0)
- Neostigmine Impurity 5 (CAS 3743-22-4)
- Neostigmine Impurity 6 (CAS 619-60-3)
- Neostigmine bromide Impurity 14 (CAS 14318-66-2)
Recommended Standards
- 2-(1-Hydroxyethyl)-6-methylaniline (CAS 196611-19-5)
- Rivastigmine Impurity N2 (CAS 894079-42-6)
- N-Methyl-4-methoxybenzylamine (CAS 702-24-9)
- Rivastigmine RC 1 (CAS 923035-06-7)
- Ibrutinib Impurity 144 (CAS CATO-C4X-1064144)
- Diclofenac EP Impurity A (CAS 15362-40-0)
- Ibuprofen EP Impurity G (CAS 2575516-43-5)
- N-Methyl-2-[3-(1-methylpiperidin-4-yl)-1H-indol-5-yl]ethene-1-sulfonamide (CAS 121679-24-1)
- 2-(Decylthio)-6-methylpyrimidin-4(1H)-one (CAS 138468-65-2)
- 1-(5-Bromo-2-methoxyphenyl)cyclobutanamine (CAS 1314743-71-9)
- 2-(Methylthio)-9H-purine-6,8-diol (CAS 14443-37-9)
- 1,2-Diamino-4-(trifluoromethoxy)benzene (CAS 658-89-9)
- N-(3-Amino-2-methylphenyl)-2-[4-(tert-butyl)-phenoxy]acetamide (CAS 1020056-46-5)
- Palmitoyl Tripeptide-8 TFA salt (CAS 936544-53-5)
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