5-Chloro-2-(trifluoromethyl)pyridine CAS 349-94-0
| CAS No. | 349-94-0 |
| Molecular Formula | C6H3ClF3N |
| Molecular Weight | 181.54 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 181.54 g/mol gives 5-Chloro-2-(trifluoromethyl)pyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-Chloro-2-(trifluoromethyl)pyridine (CAS 349-94-0) is a high-purity analytical reference standard with the molecular formula C6H3ClF3N and a molecular weight of 181.54 g/mol.
The molecular framework of 5-Chloro-2-(trifluoromethyl)pyridine (C6H3ClF3N) is characterized by a nitrile group, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 5-Chloro-2-(trifluoromethyl)pyridine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H3ClF3N |
| Molecular Weight | 181.54 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 5-Chloro-3-(difluoromethyl)-2-fluoropyridine (CAS 1119718-20-5)
- 2-Chloro-4-(difluoromethyl)-3-fluoropyridine (CAS 1262413-59-1)
- 4-Chloro-2-(trifluoromethyl)pyridine (CAS 131748-14-6)
- 3-Chloro-5-(difluoromethyl)-2-fluoro-pyridine (CAS 1374659-45-6)
- 4-chloro-2,3,6-trifluoroaniline (CAS 177785-44-3)
- 4-Chloro-3-(difluoromethyl)-2-fluoropyridine (CAS 1804703-92-1)
- 2-Chloro-5-(difluoromethyl)-3-fluoropyridine (CAS 1804754-23-1)
- 2-Chloro-3-(difluoromethyl)-4-fluoropyridine (CAS 1804950-54-6)
Recommended Standards
- 4-Chloro-3-(trifluoromethyl)pyridine (CAS 387824-63-7)
- 2-Chloro-3-(difluoromethyl)-5-fluoropyridine (CAS 1374659-31-0)
- 3-Chloro-5-(trifluoromethyl)pyridine (CAS 85148-26-1)
- 2-Chloro-5-(trifluoromethyl)pyridine (CAS 52334-81-3)
- Ganhuangenin (CAS 92519-91-0)
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- N,N-Dipropylacetamide (CAS 1116-24-1)
- TRAF6 Control Peptide trifluoroacetate salt (CAS 852690-80-3)
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