Minoxidil Impurity 31 CAS 35139-68-5
| CAS No. | 35139-68-5 |
| Molecular Formula | C4H4Cl2N4O |
| Molecular Weight | 195.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 195.01 g/mol gives Minoxidil Impurity 31 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Minoxidil Impurity 31 (CAS 35139-68-5, C4H4Cl2N4O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Minoxidil Impurity 31 (C4H4Cl2N4O) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C4H4Cl2N4O |
| Molecular Weight | 195.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Minoxidil Standards
- Minoxidil EP Impurity C (CAS 1798387-81-1)
- Minoxidil Impurity 28 (CAS CATO-C4X-170028)
- Minoxidil Impurity 56 (CAS CATO-C4X-170056)
- Minoxidil Impurity 57 (CAS CATO-C4X-170057)
- Minoxidil EP Impurity E (CAS 24867-26-3)
- Minoxidil Impurity 24 (CAS CATO-C4X-170024)
- Minoxidil Impurity 40 (CAS CATO-C4X-170040)
- Minoxidil Impurity 41 (CAS CATO-C4X-170041)
Recommended Standards
- 70-23-5 Ethyl bromopyruvate Propanoic acid, 3-bromo-2-oxo-, ethyl ester Pyruvic acid, bromo-, ethyl ester (8CI) beta-Bromopyruvic acid ethyl ester EINECS 200-729-6 Ethyl 3-bromopyruvate NSC 62182 (CAS 70-23-5)
- 2,3-Dichloro-6-fluoroanisole (CAS 1017777-48-8)
- 5-Bromo-furan-2-carboxylic acid 5-bromofuran-2-carboxylic acid 5-bromo-2-furoic acid 5-bromo furan-2-carboxylic acid 5-bromo-2-furancarboxylic acid 5-bromofuroic acid 585-70-6 (CAS 585-70-6)
- 4,6-Dichloro-2-ethyl-5-fluoropyrimidine (CAS 1152109-89-1)
- Baloxavir Marboxil Impurity 230 (CAS CATO-C4X-2108230)
- Esmolol Impurity 19 (CAS 108260-84-0)
- Bilastine Impurity 10 (CAS 1638785-19-9)
- Ethyl 2-Acetyl-4-chlorobenzoate (CAS 174813-39-9)
- 2-Ethylbenzimidazole (CAS 1848-84-6)
- 2-(Phenylsulfonyl)benzaldehyde (CAS 126076-76-4)
- 1-Methyldibenzothiophene (CAS 31317-07-4)
- 2-Hydroxy-7-methoxy-2-(trichloromethyl)chroman-4-one (CAS 473565-63-8)
- {2-[4-(Methylthio)phenoxy]ethyl}amine hydrochloride (CAS 1211477-99-4)
- Semaglutide impurity 83 (CAS CATO-C4X-222683)
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