Ethyl 4,4-Difluoroacetoacetate CAS 352-24-9

Description

Compared with other compounds in its class, the molecular weight of 166.12 g/mol gives Ethyl 4,4-Difluoroacetoacetate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

Ethyl 4,4-Difluoroacetoacetate (CAS 352-24-9), molecular formula C6H8F2O3 and molecular weight 166.12 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of Ethyl 4,4-Difluoroacetoacetate (C6H8F2O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), Ethyl 4,4-Difluoroacetoacetate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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