Vincristine EP Impurity E CAS 352-69-0
| CAS No. | 352-69-0 |
| Molecular Formula | C44H56N4O8 |
| Molecular Weight | 768.94 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Vincristine EP Impurity E (CAS 352-69-0), a pharmacopoeial impurity reference standard (molecular formula C44H56N4O8, MW 768.94 g/mol) used for the identification and quantification of trace impurities in APIs.
Vincristine EP Impurity E (C44H56N4O8) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C44H56N4O8 |
| Molecular Weight | 768.94 g/mol |
| Purity | >90% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 19.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Vincristine Standards
- Vincristine EP Impurity D (CAS 3704-01-6)
- Vincristine Impurity 2 (CAS 55324-83-9)
- Vincristine Sulfate EP Impurity C (CAS 18172-50-4)
- Vincristine EP Impurity B (CAS CATO-C4X-208912)
- Vincristine Impurity 2 (CAS 910580-56-2)
- Vincristine EP Impurity H (CAS 865-21-4)
- Vincristine EP Impurity G (CAS CATO-C4X-20897)
- Vincristine Impurity 18 (CAS CATO-C4X-208918)
Recommended Standards
- Deacetylvinblastine Hydrazide (CAS 55383-37-4)
- Bacoside A (Mixture) (CAS 11028-00-5)
- 1,4-Diacetoxynaphthalene (CAS 5697-00-7)
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- Indocyanine Green Impurity 45 (CAS 53405-99-5)
- Avatrombopag Impurity 142 (CAS CATO-C4X-2234142)
- Evocalcet Impurity 14 (CAS 870964-68-4)
- N-methyl-1-(1-(piperidin-1-yl)cyclohexyl)methanamine (CAS 41805-50-9)
- Methyl 2-methoxy-4-(methylsulfonyl)benzoate (CAS 435338-94-6)
- 2-(((3-Chloro-2-methylphenyl)amino)methyl)isoindoline-1,3-dione (CAS 199803-02-6)
- 2-(2-(2-((3-Ethyl-5-methylbenzo[d]thiazol-2(3H)-ylidene)methyl)but-1-en-1-yl)-5-methylbenzo[d]thiazol-3-ium-3-yl)acetate (CAS 52749-17-4)
- Methyl 5-hydroxypyridine-2-carboxylate (CAS 30766-12-2)
- 3-Fluoro-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1220696-64-9)
- Insulin Degludec Impurity 8 (CAS CATO-C4X-21578)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com