Vincristine EP Impurity H CAS 865-21-4
| CAS No. | 865-21-4 |
| Molecular Formula | C46H58N4O9 |
| Molecular Weight | 810.97 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Vincristine EP Impurity H meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Vincristine EP Impurity H (CAS 865-21-4) is a certified pharmaceutical impurity reference standard with the molecular formula C46H58N4O9 and a molecular weight of 810.97 g/mol.
Structurally, Vincristine EP Impurity H (C46H58N4O9) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 20.0, corresponding to approximately 20 ring(s) or double-bond equivalent(s). With a molecular weight of 810.97 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C46H58N4O9 |
| Molecular Weight | 810.97 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 20.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 4 |
Related Vincristine Standards
- Vincristine Impurity 2 (CAS 910580-56-2)
- Vincristine EP Impurity B (CAS CATO-C4X-208912)
- Vincristine EP Impurity G (CAS CATO-C4X-20897)
- Vincristine Sulfate EP Impurity C (CAS 18172-50-4)
- Vincristine Impurity 18 (CAS CATO-C4X-208918)
- Vincristine Impurity 21 (CAS CATO-C4X-208921)
- Vincristine EP Impurity D (CAS 3704-01-6)
- Vincristine Impurity N1 (CAS 947527-73-3)
Recommended Standards
- Methyl (3aR,3a1R,4R,5S,5aR,10bR)-4-acetoxy-3a-ethyl-9-((3R,5R,7R,9S)-5-ethyl-5-hydroxy-9-(methoxycarbonyl)-1,4,5,6,7,8,9,10-octahydro-2H-3,7-methano[1]azacycloundecino[5,4-b]indol-9-yl)-5-hydroxy-8-methoxy-6-methyl-3a,3a1,4,5,5a,6,11,12-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate (CAS 15228-71-4)
- Lopinavir EP Impurity O (CAS CATO-C4X-168215)
- Aurodox (CAS 12704-90-4)
- (2R)-3-((hydroxy(((1S,2S,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl)oxy)phosphoryl)oxy)propane-1,2-diyl dipalmitate (CAS 156925-83-6)
- Nicorandil Impurity 21 1Nitrate 2Formate (CAS CATO-C4X-190721)
- Azacitidine Impurity 77 (CAS 2508-81-8)
- Goserelin BP Impurity 10 Acetate (CAS 65807-03-6)
- 9-propyl-3,9-diazabicyclo[4.2.1]nonane (CAS 1209702-05-5)
- 3-Ethoxy-1-phenylprop-2-en-1-one (CAS 31172-40-4)
- 2-(Tetrahydrofuran-2-yl)nicotinic acid (CAS 1823549-69-4)
- 4-(Difluoromethyl)-3-fluoro-6-methylpicolinaldehyde (CAS 1805526-66-2)
- 6-Ethyl-7-methyl-1,8-dihydroimidazo[4,5-g]indole (CAS 113711-47-0)
- Methyl 5-amino-2-oxo-1,2-dihydropyridine-3-carboxylate (CAS 89694-08-6)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
Why CATO?
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