2-Chloro-N-(2-methyl-3-(trifluoromethyl)phenyl)nicotinamide CAS 352228-22-9
| CAS No. | 352228-22-9 |
| Molecular Formula | C14H10ClF3N2O |
| Molecular Weight | 314.69 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Chloro-N-(2-methyl-3-(trifluoromethyl)phenyl)nicotinamide is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Chloro-N-(2-methyl-3-(trifluoromethyl)phenyl)nicotinamide (CAS 352228-22-9), molecular formula C14H10ClF3N2O and molecular weight 314.69 g/mol, is a CATO reference standard with documented purity and traceability.
2-Chloro-N-(2-methyl-3-(trifluoromethyl)phenyl)nicotinamide (C14H10ClF3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 2-Chloro-N-(2-methyl-3-(trifluoromethyl)phenyl)nicotinamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H10ClF3N2O |
| Molecular Weight | 314.69 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- 5-(Chloro(4-(trifluoromethyl)phenyl)methyl)benzo[d][1,3]dioxole (CAS 1417543-27-1)
- Methyl 2-chloro-4-[2-(trifluoromethyl)phenyl]benzoate (CAS 1820607-35-9)
- Methyl 2-chloro-4-[4-(trifluoromethyl)phenyl]benzoate (CAS 1820735-28-1)
- 4-Chloro-2-(4-(trifluoromethyl)phenyl)-6,8-dihydro-5H-pyrano[3,4-d]pyrimidine (CAS 1922870-68-5)
- 4-Chloro-2-(4-(trifluoromethyl)phenyl)-7,8-dihydro-5H-pyrano[4,3-d]pyrimidine (CAS 1956385-52-6)
- (Z)-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}(1-phenylethylidene)amine (CAS 326808-43-9)
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Recommended Standards
- 3-(4-chloro-1-methyl-1H-pyrazol-3-yl)-1-[2-(trifluoromethyl)phenyl]prop-2-en-1-one (CAS 287922-57-0)
- 1-(4-Pyridinyl)-1-ethanone N-[3-chloro-5-(trifluoromethyl)-2-pyridinyl]hydrazone (CAS 339111-84-1)
- 3-(4-chloro-1-methyl-1H-pyrazol-3-yl)-1-[4-(trifluoromethyl)phenyl]prop-2-en-1-one (CAS 287922-56-9)
- 1-(4-Chlorophenyl)-2-(3-(trifluoromethyl)phenoxy)ethan-1-one (CAS 338400-72-9)
- 2-Hydroxy-7-O-methylscillascillin (CAS 52096-50-1)
- 3-ISOPROPYL,5-TERT-BUTYLPYROCATECHOL (CAS 143767-20-8)
- N-(2-methoxy-5-(trifluoromethyl)phenyl)acetamide (CAS 40622-64-8)
- (4-Amino-2-methylpyrimidin-5-yl)methyl methylcarbamimidothioate (CAS 807262-22-2)
- 3-(3-Benzyl-1,2,4-oxaDiazol-5-yl)propan-1-amine (CAS 926194-70-9)
- 4-(1,3-Dithiolan-2-yl)benzoic Acid (CAS 101033-03-8)
- 4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide (CAS 1020253-05-7)
- Vilazodone Impurity 4 (CAS 2044702-50-1)
- 27832-15-1 10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-, N-oxide DTXSID20182150 (CAS 27832-15-1)
- Peptide WE-14 (CAS 115136-18-0)
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