3-Chloro-4-hydroxy-5-methylbenzoic acid CAS 35458-34-5
| CAS No. | 35458-34-5 |
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-Chloro-4-hydroxy-5-methylbenzoic acid.
3-Chloro-4-hydroxy-5-methylbenzoic acid (CAS 35458-34-5), molecular formula C8H7ClO3 and molecular weight 186.59 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 3-Chloro-4-hydroxy-5-methylbenzoic acid is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 186.59 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-4-hydroxy-5-methylbenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7ClO3 |
| Molecular Weight | 186.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
Related Chloro Standards
- 4-Chloro-2-(hydroxymethyl)benzoic acid (CAS 100448-59-7)
- Methyl 2-Chloro-4-hydroxybenzoate (CAS 104253-44-3)
- 3-Chloro-2,4-dihydroxy-6-methylbenzaldehyde (CAS 106325-72-8)
- 2-Chloro-4-(hydroxymethyl)benzoic acid (CAS 1071989-48-4)
- Methyl 2-chloro-3-hydroxybenzoate (CAS 1125632-11-2)
- 2-Chloro-6-hydroxy-4-methoxybenzaldehyde (CAS 116475-68-4)
- 2-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-13-6)
- 4-Chloro-3-(hydroxymethyl)benzoic acid (CAS 1187238-15-8)
Recommended Standards
- 3-Chloro-4,6-dihydroxy-2-methylbenzaldehyde (CAS 83324-59-8)
- 3-Chloro-4-Methoxybenzoic Acid (CAS 37908-96-6)
- 3-Chloro-2-hydroxy-6-methylbenzoic acid (CAS 89938-57-8)
- 3-Chloro-5-hydroxy-4-methoxybenzaldehyde (CAS 54246-06-9)
- 7-Chloro-3-(2-chlorobenzyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine (CAS 201541-70-0)
- 2-(Dimethylamino)-3,3-dimethylpent-4-enamide (CAS 88471-89-0)
- Phthalic Acid 1-(1,2-dimethylpropyl) Ester (CAS 198284-10-5)
- 1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-, polymer with 1,2-ethanediol and 1,2,3-propanetriol (CAS 65970-35-6)
- (R)-2,2,2-Trifluoro-1-(pyridin-2-yl)ethanamine (CAS 1228565-87-4)
- H-Ser-NH2 · HCl (CAS 65414-74-6)
- 7-Bromo-1H-indazol-6-amine (CAS 139502-26-4)
- 1-Chloro-4-((4-(3-chloroprop-1-yn-1-yl)phenoxy)methyl)benzene (CAS 1178666-08-4)
- tert-Butyl (S)-3-(1H-1,2,3-triazol-5-yl)azepane-1-carboxylate (CAS 2381149-47-7)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
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