Favipiravir Impurity 20 CAS 356783-49-8
| CAS No. | 356783-49-8 |
| Molecular Formula | C5HClFN3 |
| Molecular Weight | 157.53 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Favipiravir Impurity 20.
As a process- or degradation-related impurity, Favipiravir Impurity 20 (CAS 356783-49-8, C5HClFN3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C5HClFN3, Favipiravir Impurity 20 contains a nitrile group, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 157.53 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5HClFN3 |
| Molecular Weight | 157.53 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Favipiravir Standards
- Favipiravir Impurity 37 (CAS 259794-01-9)
- Favipiravir (CAS 259793-96-9)
- Favipiravir Impurity 9 (CAS 1079990-21-8)
- Favipiravir Impurity 21 (CAS 1207609-52-6)
- Favipiravir Impurity 8 (CAS 356783-29-4)
- Favipiravir Impurity 6 (CAS 1374986-27-2)
- Favipiravir Impurity 15 (CAS CATO-C4X-210215)
- Favipiravir-13C3 (CAS CATO-C4X-210210)
Recommended Standards
- 2-Chloro-5-fluoropyrimidine-4-carbonitrile (CAS 1811512-52-3)
- 4-Chloronicotinic Acid (CAS 10177-29-4)
- 2-Bromo-1-chloropropane (CAS 3017-95-6)
- 4-Chloro-5-hydroxypicolinaldehyde (CAS 1060804-51-4)
- Olaparib Impurity 164 (CAS CATO-C4X-1135164)
- Nortriptyline EP Impurity J (CAS 4317-14-0)
- Olopatadine Impurity 11 (CAS 56427-76-0)
- 4-(oxan-4-yl)phenol (CAS 62071-41-4)
- (1R,2R)-2-phenylcyclobutan-1-amine (CAS 1969288-18-3)
- 2-(Methylsulfinyl)pyrimidin-5-ol (CAS 49547-41-3)
- 2-(9H-carbazol-9-yl)-4-methylphenol (CAS 620987-78-2)
- 2,5-Difluorotoluene (CAS 452-67-5)
- methyl 3-(iodomethyl)cyclobutanecarboxylate (CAS 2411638-83-8)
- Palmitoyl Hexapeptide-12 TFA salt (CAS 171263-26-6(Free Base))
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