Varenicline Impurity C01 CAS 357424-22-7
| CAS No. | 357424-22-7 |
| Molecular Formula | C11H14N2 |
| Molecular Weight | 174.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Varenicline Impurity C01 is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Varenicline Impurity C01 (CAS 357424-22-7, C11H14N2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Varenicline Impurity C01 (C11H14N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 174.24 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Varenicline Impurity C01 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H14N2 |
| Molecular Weight | 174.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 2 |
Related Varenicline Standards
- Varenicline Impurity 32 (CAS 26326-70-5)
- Varenicline Impurity 39 (CAS 608-89-9)
- Varenicline Impurity 46 (CAS CATO-C4X-196246)
- Varenicline Impurity 27 (CAS 950781-91-6)
- Varenicline Impurity 59 (CAS CATO-C4X-196259)
- Varenicline Impurity C61 (CAS 357424-12-5)
- Varenicline Impurity 49 (CAS CATO-C4X-196249)
- Varenicline (CAS 249296-44-4)
Recommended Standards
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- tert-Butyl 3-hydroxy-2,2-dimethylpropanoate (CAS 25307-76-0)
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- tert-Butyl (4-fluoro-5-formylthiazol-2-yl)carbamate (CAS 2241514-59-8)
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- CAS 326495-38-9 (CAS 326495-38-9)
- 1-(6-Methylpyrimidin-4-yl)piperidin-4-amine dihydrochloride (CAS 1329673-44-0)
- Peptide Impurity 06 (CAS CATO-CPTD788806)
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