(1R,5S)-7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine CAS 357425-02-6
| CAS No. | 357425-02-6 |
| Molecular Formula | C12H12F3N |
| Molecular Weight | 227.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (1R,5S)-7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies (1R,5S)-7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine (CAS 357425-02-6), a certified reference material (molecular formula C12H12F3N, MW 227.23 g/mol) for analytical method development and quality control.
The molecular framework of (1R,5S)-7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine (C12H12F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H12F3N |
| Molecular Weight | 227.23 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- (1-((3,3-Difluoroazetidin-1-yl)sulfonyl)cyclopropyl)methanol (CAS 2412841-49-5)
- (1S,5R)-7-(Trifluoromethyl)-2,3,4,5-tetrahydro-1H-1,5-methanobenzo[d]azepine (CAS 357425-68-4)
- 1-Butoxy-5-fluoro-4-methyl-2-nitrobenzene (CAS 1872536-47-4)
- 1-(2-(Trifluoromethyl)phenyl)-3-azabicyclo[3.1.0]Hexane (CAS 863679-47-4)
- 3-(4-Chlorophenoxy)azetidine hydrochloride (CAS 490021-97-1)
- 4-Hydroxy-7-(methylamino)naphthalene-2-sulfonic acid (CAS 22346-43-6)
- 2-((2-Methoxyethyl)amino)-4-methylpyrimidine-5-carboxylic acid (CAS 1189002-79-6)
- 3-[(Cyclopropylamino)sulfonyl]benzoic Acid (CAS 852933-50-7)
- ((1S,2S)-2-Aminocyclopentyl)methanol hydrochloride (CAS 2550996-41-1)
- 1-(aminomethyl)-3,3-dimethylcyclohexan-1-ol hydrochloride (CAS 911010-82-7)
- 3-(3-Bromophenyl)-1-methyl-1H-pyrazole (CAS 425379-68-6)
- Delafloxacin Impurity 22 (CAS CATO-C4X-263722)
- 2-((3-(Benzylsulfonyl)-5-nitrophenyl)thio)acetic acid (CAS 883291-52-9)
- Semaglutide Impurity 140 (CAS CATO-C4X-2226140)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com