3-Bromo-4-chloro-5-fluoroaniline CAS 35754-27-9
| CAS No. | 35754-27-9 |
| Molecular Formula | C6H4BrClFN |
| Molecular Weight | 224.46 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-Bromo-4-chloro-5-fluoroaniline (CAS 35754-27-9), molecular formula C6H4BrClFN and molecular weight 224.46 g/mol, is a CATO reference standard with documented purity and traceability.
3-Bromo-4-chloro-5-fluoroaniline (C6H4BrClFN) contains a nitrile group, fluorine/chlorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4BrClFN |
| Molecular Weight | 224.46 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | F/Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 4-Bromo-2-chloro-5-fluoroaniline (CAS 1000572-63-3)
- 5-Bromo-4-chloro-2-fluoroaniline (CAS 111010-07-2)
- (4-BROMO-3-CHLORO-2-FLUOROPHENYL)AMINE 115843-99-7 4-BROMO-3-CHLORO-2-FLUOROANILINE 4-BROMO-3-CHLORO-2-FLUOROBENZENAMINE BC002759 BUTTPARK 89\07-45 (CAS 115843-99-7)
- 4-Bromo-5-chloro-2-fluoroaniline (CAS 116369-24-5)
- 2-Bromo-4-chloro-5-fluoroaniline (CAS 120694-11-3)
- 3-Bromo-6-chloro-5-fluoro-2-methylpyridine (CAS 1211520-20-5)
- 2-Bromo-5-(chloromethyl)-3-fluoropyridine (CAS 1227489-73-7)
- 2-Bromo-4-(chloromethyl)-5-fluoropyridine (CAS 1227493-80-2)
Recommended Standards
- 2-Bromo-6-chloro-4-fluoroaniline (CAS 201849-14-1)
- 3-Bromo-6-chloro-2-fluoroaniline (CAS 943830-81-7)
- 2-Bromo-5-chloro-4-fluoroaniline (CAS 85462-59-5)
- 4-Bromo-2-chloro-6-fluoroaniline (CAS 885453-49-6)
- 2-Amino-N-ethyl-3-(1H-imidazol-5-yl)propanamide (CAS 1351384-89-8)
- Methyl benzo[b]oxepine-4-carboxylate (CAS 174633-80-8)
- (4,5-Dichloro-1H-pyrrol-2-yl)methanol (CAS 1936490-60-6)
- Abiraterone Impurity 59 (CAS CATO-C4X-107059)
- Methyl 2-(difluoromethoxy)-4-nitrobenzoate (CAS 1219014-86-4)
- 4-(1-Iodovinyl)-1,1'-biphenyl (CAS 2252246-41-4)
- Indometacin EP Impurity A (CAS 74-11-3)
- Methyl 3-(3-benzoylthioureido)-3-(4-bromophenyl)propanoate (CAS 691873-23-1)
- 3-(4-Bromo-2-fluorophenyl)propan-1-ol (CAS 1057671-56-3)
- Liraglutide Impurity 13 TFA Salt (CAS CATO-C4X-199213)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com