Indometacin EP Impurity A CAS 74-11-3
| CAS No. | 74-11-3 |
| Molecular Formula | C7H5ClO2 |
| Molecular Weight | 156.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Indometacin EP Impurity A.
CATO supplies Indometacin EP Impurity A (CAS 74-11-3), a pharmacopoeial impurity reference standard (molecular formula C7H5ClO2, MW 156.57 g/mol) used for the identification and quantification of trace impurities in APIs.
Indometacin EP Impurity A (C7H5ClO2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Indometacin EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5ClO2 |
| Molecular Weight | 156.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Indometacin Standards
- Indometacin Impurity 64 (CAS CATO-C4X-147064)
- Indometacin Impurity 45 (CAS CATO-C4X-147045)
- Indometacin Impurity 17 (CAS 10414-67-2)
- Indometacin Impurity 25 (CAS CATO-C4X-147025)
- Indometacin Impurity 26 (CAS CATO-C4X-147026)
- Indometacin EP Impurity B (CAS 2882-15-7)
- Indometacin Impurity 20 (CAS 73301-01-6)
- Indometacin Impurity 27 (CAS CATO-C4X-147027)
Recommended Standards
- Tizanidine Impurity 52 (CAS CATO-C4X-144552)
- 2-Chloro-1-fluoro-4-vinylbenzene (CAS 1011029-41-6)
- Mesalazine EP Impurity L (CAS 118-91-2)
- 1-Chloro-4-(1-fluorovinyl)benzene (CAS 106263-12-1)
- Linezolid Ipurity 84 (CAS CATO-C4X-107384)
- Pidotimod Impurity 7 (CAS CATO-C4X-10787)
- Ibuprofen Impurity 77 (CAS CATO-C4X-108277)
- 1-Bromo-2-(3-chloropropyl)benzene (CAS 57918-67-9)
- Molsidomine EP Impurity C (CAS 26179-71-5)
- 4-Formyl-2-(trifluoromethyl)benzoic acid (CAS 1289087-72-4)
- Ethyl 5-amino-1H-imidazole-4-carboxylate hydrochloride (CAS 118019-42-4)
- 3-(2-Methylcyclopropyl)-3-oxopropanenitrile (CAS 1152599-39-7)
- Udenafil Impurity 3 (CAS CATO-C4X-33723)
- Semaglutide Impurity 152 xTFA (CAS CATO-C4X-2226152)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com