2,8-Bis(trifluoromethyl)-4-hydroxyquinoline CAS 35853-41-9
| CAS No. | 35853-41-9 |
| Molecular Formula | C11H5F6NO |
| Molecular Weight | 281.15 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2,8-Bis(trifluoromethyl)-4-hydroxyquinoline (CAS 35853-41-9) is a high-purity analytical reference standard with the molecular formula C11H5F6NO and a molecular weight of 281.15 g/mol.
Structurally, 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline (C11H5F6NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 7.0, corresponding to approximately 7 ring(s) or double-bond equivalent(s). With a molecular weight of 281.15 g/mol, it falls into the medium-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO manufactures 2,8-Bis(trifluoromethyl)-4-hydroxyquinoline under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H5F6NO |
| Molecular Weight | 281.15 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 2,4-Bis(trifluoromethyl)quinolin-7-ol (CAS 91915-69-4)
- 2,6-Bis(trifluoromethyl)-4-hydroxyquinoline (CAS 35877-04-4)
- 3-(3,5-Bis(trifluoromethyl)phenyl)-3-oxopropanenitrile (CAS 267880-81-9)
- 5-(2,4-Bis(trifluoromethyl)phenyl)oxazole (CAS 2364585-25-9)
- 5-(3,5-Bis(trifluoromethyl)phenyl)oxazole (CAS 2364584-77-8)
- 5,7-Bis(trifluoromethyl)quinolin-4(1H)-one (CAS 237076-72-1)
- 5-[3,5-Bis(trifluoromethyl)phenyl]-1H-1,2,4-triazole (CAS 1333154-10-1)
- 5,7-Bis(trifluoromethyl)-1,8-naphthyridin-2-amine (CAS 51420-72-5)
Recommended Standards
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- 3-(2-Bromoethyl)-2,8-dimethyl-4H-pyrido[1,2-a]pyrimidin-4-one (CAS 59484-91-2)
- tert-Butyl 2-((2R,4R)-4-hydroxypiperidin-2-yl)acetate (CAS 2667654-54-6)
- 3-Hydroxy-4-(trifluoromethyl)benzonitrile (CAS 731002-50-9)
- 4-Chloro-1H-pyrazole-3-carbaldehyde (CAS 623570-54-7)
- Ethyl Isovalerate (CAS 108-64-5)
- Cilostazol impurity 11 (CAS 54197-64-7)
- 2-(6-(4-Methoxyphenyl)-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl)acetic acid (CAS 870692-87-8)
- 3-Benzyl-3-chloroindolin-2-one (CAS 1398681-74-7)
- 1-(3-(tert-Butyl)-1-(3-methoxy-4-methylphenyl)-1H-pyrazol-5-yl)-3-(2-((2-chloropyrimidin-4-yl)oxy)benzyl)urea (CAS 940871-00-1)
- 4-Methoxybenzyl (E)-styrylcarbamate (CAS 338413-37-9)
- Acetyl Hexapeptide-39 (CAS 1382088-38-1)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com