Propranolol EP Impurity A CAS 36112-95-5
| CAS No. | 36112-95-5 |
| Molecular Formula | C13H14O3 |
| Molecular Weight | 218.25 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Propranolol EP Impurity A (CAS 36112-95-5) is a certified pharmaceutical impurity reference standard with the molecular formula C13H14O3 and a molecular weight of 218.25 g/mol.
The molecular framework of Propranolol EP Impurity A (C13H14O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Propranolol EP Impurity A meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H14O3 |
| Molecular Weight | 218.25 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
Related Propranolol Standards
- Propranolol Impurity 7 (CAS 34646-56-5)
- Propranolol Impurity N5 (CAS 20862-11-7)
- Propranolol Impurity 19 (CAS 62618-09-1)
- Propranolol Impurity 29 (CAS 20862-12-8)
- Propranolol Impurity 12 (CAS 13917-61-8)
- Propranolol Impurity 16 (CAS 5234-06-0)
- Propranolol Impurity 56 (CAS CATO-C4X-151956)
- Propranolol Impurity 59 (CAS CATO-C4X-151959)
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