Nisoldipine Impurity 4 CAS 87375-91-5
| CAS No. | 87375-91-5 |
| Molecular Formula | C20H22N2O5 |
| Molecular Weight | 370.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, Nisoldipine Impurity 4 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 370.40 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Nisoldipine Impurity 4 (CAS 87375-91-5) is a certified pharmaceutical impurity reference standard with the molecular formula C20H22N2O5 and a molecular weight of 370.40 g/mol.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nisoldipine Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H22N2O5 |
| Molecular Weight | 370.40 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1981 |
| Nitrogen Atoms | 2 |
Related Nisoldipine Standards
- Nisoldipine USP Related Compound D (CAS 103026-83-1)
- Nisoldipine Impurity 3 (CAS CATO-C4X-18653)
- Nisoldipine (CAS 63675-72-9)
- (±)-Nisoldipine-d4 (2-nitrophenyl-d4) (CAS 1219795-47-7)
- Nisoldipine Impurity 4 (CAS 106685-70-5)
- Nisoldipine Impurity 1 (CAS 2226462-71-9)
- Nisoldipine Impurity 2 (CAS CATO-C4X-18652)
- Nisoldipine Impurity 6 (CAS 61312-59-2)
Recommended Standards
- Epinastine Impurity 39 (CAS CATO-C4X-184039)
- Icaritin Impurity 11 (CAS CATO-C4X-276411)
- Adapalene Impurity 10 (CAS 161912-38-5)
- Marbofloxacin-d8 (CAS 1185053-37-5)
- Landiolol Impurity 25 (CAS CATO-C4X-262125)
- Ceftazidime Impurity 27 (CAS 83654-89-1)
- Tulobuterol Impurity N5 (CAS 72702-57-9)
- Flurbiprofen Impurity 115 (CAS CATO-C4X-1444115)
- (3-((5-Bromopyridin-2-yl)oxy)phenyl)methanol (CAS 119349-41-6)
- 17:0-20:4 PI (3,4) P2 (CAS 1144099-87-5)
- 2-(4-Hydroxy-6-methoxypyridin-2-yl)acetic acid (CAS 1393539-73-5)
- 2-(4'-(Trifluoromethoxy)-[1,1'-biphenyl]-3-yl)acetic acid (CAS 1224742-16-8)
- 4h-1,2,4-Triazole-3,4-diamine hydrobromide (CAS 23160-99-8)
- Liraglutide Impurity 19 TFA Salt (CAS CATO-C4X-199219)
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