Posaconazole Impurity 114 CAS 364-83-0
| CAS No. | 364-83-0 |
| Molecular Formula | C8H6F2O |
| Molecular Weight | 156.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Posaconazole Impurity 114 (CAS 364-83-0, C8H6F2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Posaconazole Impurity 114 (C8H6F2O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F2O |
| Molecular Weight | 156.13 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Posaconazole Standards
- Posaconazole Impurity 116 (CAS 151670-13-2)
- Posaconazole Impurity 118 (CAS 81445-45-6)
- Posaconazole Impurity 85 (CAS 81445-44-5)
- Posaconazole Impurity 115 (CAS 122151-38-6)
- Posaconazole impurity 245 (CAS CATO-C4X-1208245)
- Posaconazole Impurity 58 (CAS 141113-36-2)
- Posaconazole Impurity 148 (CAS 132489-33-9)
- Posaconazole Impurity 152 (CAS 132489-34-0)
Recommended Standards
- (S)-2-(3,4-difluorophenyl)oxirane (CAS 1006376-63-1)
- 2-Amino-2-(3-methylisoxazol-5-yl)acetic acid (CAS 100114-42-9)
- , -Difluoroacetophenone 2,2-Difluoro-1-phenylethanone 2,2-Difluoroacetophenone 395-01-7 Difluoromethyl phenyl ketone a,a-difluoroacetophenone alpha,alpha-difluoroacetophenone (CAS 395-01-7)
- 1-(Methoxymethyl)-1h-pyrazole-3-carboxylic acid (CAS 1001500-66-8)
- Benserazide Impurity 59 (CAS CATO-C4X-142759)
- Atropine Impurity 31 (CAS CATO-C4X-148931)
- Avibactam Impurity 126 (CAS CATO-C4X-1348126)
- 4-Methyl-3-(p-tolyl)pentanoic acid (CAS 57960-10-8)
- 2-Bromo-6-(difluoromethyl)-4-nitronicotinonitrile (CAS 1805164-86-6)
- 3-cyclopropylmethanesulfonyl-2,6-difluorobenzoic acid (CAS 1156165-34-2)
- 1-(2-Methyl-6-(piperazin-1-yl)pyridin-3-yl)propan-1-ol (CAS 1355173-87-3)
- Ixazomib Impurity 79 (CAS 389799-97-7)
- 2-(Difluoromethyl)-6-methyl-5-nitropyridine-3-acetonitrile (CAS 1805465-77-3)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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