Adrenaline EP Impurity E CAS 36467-25-1
| CAS No. | 36467-25-1 |
| Molecular Formula | C16H17NO3 |
| Molecular Weight | 271.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 271.31 g/mol gives Adrenaline EP Impurity E distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Adrenaline EP Impurity E (CAS 36467-25-1, C16H17NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C16H17NO3, Adrenaline EP Impurity E contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 271.31 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H17NO3 |
| Molecular Weight | 271.31 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >90% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 1 |
Related Adrenaline Standards
- Adrenaline Impurity 34 (CAS 1095714-91-2)
- Adrenaline EP Impurity D (CAS 317351-40-9)
- Adrenaline Impurity 28 (CAS CATO-C4X-184928)
- Adrenaline Impurity 88 (CAS 139183-81-6)
- Adrenaline Impurity 93 (CAS CATO-C4X-184993)
- Adrenaline Impurity 95 (CAS 2972574-99-3)
- Adrenaline Impurity 27 (CAS CATO-C4X-184927)
- Adrenaline Impurity 86 (CAS CATO-C4X-184986)
Recommended Standards
- Epinephrine /Adrenaline Impurity 104 (CAS CATO-C4X-1849104)
- Dopamine Impurity 104 (CAS CATO-C4X-1908104)
- Doxylamine Impurity 15 (CAS CATO-C4X-178915)
- Apomorphine impurity 3 (CAS CATO-C4X-21173)
- Articaine EP Impurity E HCl (CAS 1796888-45-3(free base))
- Rifamycin Impurity 15 (CAS CATO-C4X-200414)
- Famotidine Impurity 82 (CAS CATO-C4X-139282)
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