Zidovudine Impurity N1 CAS 365-07-1
| CAS No. | 365-07-1 |
| Molecular Formula | C10H15N2O8P |
| Molecular Weight | 322.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Zidovudine Impurity N1 is closely related to a carbohydrate-derived structure, an amide group, a phosphate ester group in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Zidovudine Impurity N1 (CAS 365-07-1) is a certified pharmaceutical impurity reference standard with the molecular formula C10H15N2O8P and a molecular weight of 322.21 g/mol.
Zidovudine Impurity N1 (C10H15N2O8P) contains a carbohydrate-derived structure, an amide group, a phosphate ester group. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H15N2O8P |
| Molecular Weight | 322.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Zidovudine Standards
- Zidovudine Monophosphate (CAS 29706-85-2)
- Zidovudine EP Impurity K (CAS 596-31-6)
- Zidovudine-d4 (CAS CATO-C4X-178320)
- Zidovudine Impurity 04 (CAS 73971-82-1)
- Zidovudine Impurity 13 (CAS 123606-70-2)
- Zidovudine EP Impurity B (CAS 25526-94-7)
- Zidovudine EP Impurity D (CAS 76-84-6)
- Zidovudine Impurity F (CAS 16053-52-4)
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