Avanafil Impurity 80 CAS 366825-49-2
| CAS No. | 366825-49-2 |
| Molecular Formula | C7H8ClNO |
| Molecular Weight | 157.60 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Avanafil Impurity 80.
Avanafil Impurity 80 (CAS 366825-49-2) is a certified pharmaceutical impurity reference standard with the molecular formula C7H8ClNO and a molecular weight of 157.60 g/mol.
Owing to an amide group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Avanafil Impurity 80 is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 157.60 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H8ClNO |
| Molecular Weight | 157.60 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Avanafil Standards
Recommended Standards
- Lansoprazole impurity 75 (CAS 1805648-51-4)
- Rabeprazole Impurity 40 (CAS 59886-90-7)
- 3-(Aminomethyl)-5-chlorophenol 862541-23-9 KS-00003SMQ (CAS 862541-23-9)
- Ilaprazole Impurity 76 (CAS 59886-85-0)
- Apixaban Impurity 145 (CAS CATO-C4X-1088145)
- Ceritinib Impurity 36 (CAS CATO-C4X-104836)
- Gefitinib Impurity 7 (CAS 184475-71-6)
- P-Xylene (CAS 106-42-3)
- Daptomycin Impurity 37 (CAS CATO-C4X-137837)
- 5-(Dimethoxymethyl)-1-(2-nitrophenyl)-1H-pyrazole (CAS 1269291-82-8)
- Methyl 3-(4-chlorosulfonyl)phenylpropionate (CAS 374537-95-8)
- N-(Furan-2-ylmethyl)thiophene-2-carboxamide (CAS 293765-00-1)
- 2-(2-Bromophenyl)benzo[d]oxazole-5-carboxamide (CAS 1706452-06-3)
- Biotinyl-Neuropeptide Y (human, rat) trifluoroacetate salt (CAS 213779-13-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com