Gefitinib Impurity 7 CAS 184475-71-6
| CAS No. | 184475-71-6 |
| Molecular Formula | C15H11ClFN3O2 |
| Molecular Weight | 319.72 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 319.72 g/mol gives Gefitinib Impurity 7 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
Gefitinib Impurity 7 (CAS 184475-71-6) is a certified pharmaceutical impurity reference standard with the molecular formula C15H11ClFN3O2 and a molecular weight of 319.72 g/mol.
Based on its molecular formula C15H11ClFN3O2, Gefitinib Impurity 7 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 319.72 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H11ClFN3O2 |
| Molecular Weight | 319.72 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2009 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Gefitinib Standards
- Gefitinib impurity 64 (CAS CATO-C4X-111764)
- Gefitinib EP Impurity A (CAS 199327-61-2)
- Gefitinib Impurity 41 (CAS CATO-C4X-111741)
- Gefitinib Impurity 48 (CAS 1006378-06-8)
- Gefitinib Impurity 54 (CAS 675126-26-8)
- Gefitinib impurity 68 (CAS CATO-C4X-111768)
- Gefitinib impurity 69 (CAS CATO-C4X-111769)
- Gefitinib Impurity 89 (CAS CATO-C4X-111789)
Recommended Standards
- 4-((3-Chloro-2-fluorophenyl)amino)-7-methoxyquinazolin-6-ol (CAS 612501-52-7)
- Selumetinib Impurity 16 (CAS CATO-C4X-305316)
- 4-((4-Chloro-2-fluorophenyl)amino)-6-methoxyquinazolin-7-ol (CAS 193001-59-1)
- 3-(4-Chlorophenyl)sulfanyl-1-methyl-5-(trifluoromethyl)pyridin-2-one (CAS 1924322-42-8)
- Palbociclib impurity 163 (CAS CATO-C4X-1125163)
- Amlodipine Impurity N20 (CAS 2170104-02-4)
- Afatinib Impurity 32 (CAS 2170273-17-1)
- (3-Fluoro-2-nitrophenyl)hydrazine (CAS 435281-10-0)
- 3-Fluoro-5-(methylthio)phenol (CAS 1243456-31-6)
- 4-(1,3-Dioxaindan-5-yl)-3-methyl-1h-pyrazol-5-amine (CAS 1187767-29-8)
- 5,7-Dichloroimidazo[1,2-a]pyrimidine hydrochloride (CAS 1858249-97-4)
- 3-(4-Chlorophenyl)-2-phenoxyquinoline (CAS 339103-61-6)
- (1R)-1-(3-fluoropyridin-2-yl)ethan-1-ol (CAS 1568238-76-5)
- GnRH Associated Peptide (GAP) (1-13), human (CAS 100111-07-7)
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