4-Bromo-2-fluoroaniline CAS 367-24-8
| CAS No. | 367-24-8 |
| Molecular Formula | C6H5BrFN |
| Molecular Weight | 190.01 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Bromo-2-fluoroaniline (CAS 367-24-8) is a high-purity analytical reference standard with the molecular formula C6H5BrFN and a molecular weight of 190.01 g/mol.
The molecular framework of 4-Bromo-2-fluoroaniline (C6H5BrFN) is characterized by a nitrile group, fluorine/bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H5BrFN |
| Molecular Weight | 190.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-Bromo-4-fluoroaniline (CAS 1003-98-1)
- 2-Bromo-3-fluoroaniline (CAS 111721-75-6)
- 5-Bromo-3-fluoro-2-methylpyridine (CAS 1162674-74-9)
- 3-Bromo-5-fluoro-4-methylpyridine (CAS 1211517-76-8)
- 2-Bromo-4-fluoro-6-methylpyridine (CAS 1211526-18-9)
- 3-Bromo-4-fluoro-2-methylpyridine (CAS 1211528-46-9)
- 5-Bromo-4-fluoro-2-methylpyridine (CAS 1211532-14-7)
- 4-Bromo-3-fluoro-5-methylpyridine (CAS 1211533-99-1)
Recommended Standards
- 2,4-Dimethoxypyrimidine-5-boronic acid 2,4-dimethoxypryimidine-5-boronic acid (2,4-dimethoxypyrimidin-5-yl)boronic acid (2,4-dimethoxypyrimidin-5-yl)boranediol 2,4-dimethoxy-5-pyrimidineboronic acid 89641-18-9 (CAS 89641-18-9)
- 2-Bromo-6-fluoroaniline (CAS 65896-11-9)
- N-(n-Butyl)-phosphoramidic Dichloride (CAS 90206-85-2)
- Tedizolid Impurity 61 (CAS 656-65-5)
- 286013-18-1 dimethyl sulfate (13c2) (CAS 286013-18-1)
- 1-Ethyl-n-phenylpiperidin-4-amine (CAS 229479-52-1)
- 2-(Bicyclo[2.2.1]Heptan-2-ylamino)-N,N-dimethylacetamide (CAS 1247416-22-3)
- N-(3,5-Dichloro-4-pyridinyl)-8-methoxy-5-quinolinecarboxamide (CAS 199871-63-1)
- Phenyl(2-(quinolin-6-yl)pyrrolidin-1-yl)methanone (CAS 1355231-06-9)
- 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium iodide (CAS 14134-81-7)
- 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-(dimethylamino)cyclohexyl]amino]-3-cyclobutene-1,2-dione (CAS 1263205-96-4)
- 2-{[(2,6-dichlorophenyl)methyl]sulfanyl}-4-[(E)-2-phenylethenyl]pyrimidine (CAS 338407-62-8)
- 5-Bromo-4-chloro-3-nitroquinoline (CAS 723283-91-8)
- Cyclopeptide-5 (CAS 197172-76-2)
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