Bicalutamide Impurity 10 CAS 367-67-9
| CAS No. | 367-67-9 |
| Molecular Formula | C7H3BrF3NO2 |
| Molecular Weight | 270.00 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Bicalutamide Impurity 10.
As a process- or degradation-related impurity, Bicalutamide Impurity 10 (CAS 367-67-9, C7H3BrF3NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Bicalutamide Impurity 10 (C7H3BrF3NO2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 270.00 g/mol, it falls into the medium-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3BrF3NO2 |
| Molecular Weight | 270.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bicalutamide Standards
- Bicalutamide Impurity 14 (Bicalutamide Epoxide Impurity) (CAS 90357-51-0)
- Bicalutamide Impurity 21 (CAS 71515-96-3)
- Bicalutamide Impurity 34 (CAS CATO-C4X-101334)
- Bicalutamide EP Impurity M (CAS 151262-57-6)
- Bicalutamide Impurity 22 (CAS 405-31-2)
- Bicalutamide Impurity 13 (CAS 90357-53-2)
- Bicalutamide Impurity 23 (CAS 2905-15-9)
- Bicalutamide Impurity 20 (CAS 316373-92-9)
Recommended Standards
- PUE9VR0TBW 93-52-7 1,2-Dibromo-1-phenylethane Benzene, (1,2-dibromoethyl)- 1,2-Dibromo(phenyl)ethane 4-05-00-00909 (Beilstein Handbook Reference) AI3-17377 BRN 0907323 CCRIS 2090 alpha,beta-Dibromoethylbenzene (1,2-Dibromoethyl)benzene 1,2-Dibromo-2-phenylethane Dowspray 9 EINECS 202-253-4 NSC 62438 vic-Styrene dibromide UNII-PUE9VR0TBW (CAS 93-52-7)
- (3-Methoxy-4-nitrophenyl)phosphonic dichloride (CAS 1197956-37-8)
- 1,2-Bis(bromomethyl)benzene 1,2-DIBENZYL BROMIDE 91-13-4 A,A'-DIBROMO-O-XYLENE A,A-DIBROMO-O-XYLENE ALPHA,ALPHA'-DIBROMO-2-XYLENE ALPHA,ALPHA'-DIBROMO-O-XYLENE ALPHA,ALPHA-DIBROMO-O-XYLENE AS00651 ATTERCOP-CHM AT113229 O-XYLIDENE DIBROMIDE O-XYLYLENE BROMIDE O-XYLYLENE DIBROMIDE SPEC-INF-BB S2183 (CAS 91-13-4)
- N-(5-bromopyrazin-2-yl)-2,2,2-trifluoroacetamide (CAS 1487273-20-0)
- Alectinib impurity 24 (CAS 1256585-32-6)
- Benidipine Impurity 45 (CAS CATO-C4X-112045)
- Lenacapavir Impurity 89 (CAS CATO-C4X-32489)
- 1-(3-Bromophenyl)-3-((4-ethoxyphenyl)amino)propan-1-one (CAS 883794-18-1)
- N-(2-Amino-4-methylphenyl)butanamide (CAS 861534-82-9)
- 3-(4-Fluoro-3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole (CAS 1262413-14-8)
- (E)-4-Ethylidene-5-methyl-3-(propan-2-ylidene)pyrrolidin-2-one (CAS 37817-45-1)
- Sodium 4-methyl-2-oxo-2H-chromen-7-olate (CAS 5980-33-6)
- 4,4′-[Methylenebis(4,1-phenyleneimino)]bis[4-oxobutanoic acid] (CAS 155267-38-2)
- Uremic Pentapeptide (CAS 71494-20-7)
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