Imatinib Impurity N13 CAS 36747-64-5
| CAS No. | 36747-64-5 |
| Molecular Formula | C8H5Cl3O |
| Molecular Weight | 223.48 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Imatinib Impurity N13 (C8H5Cl3O) is characterized by a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies Imatinib Impurity N13 (CAS 36747-64-5), a pharmacopoeial impurity reference standard (molecular formula C8H5Cl3O, MW 223.48 g/mol) used for the identification and quantification of trace impurities in APIs.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5Cl3O |
| Molecular Weight | 223.48 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
Related Imatinib Standards
- Imatinib Impurity 75 (CAS CATO-C4X-106875)
- Imatinib Impurity 59 (CAS 220213-15-0)
- Imatinib Impurity 58 (CAS 125743-63-7)
- Imatinib Impurity 35 (CAS CATO-C4X-106835)
- Imatinib Impurity 55 (CAS 514209-42-8)
- Imatinib Impurity 48 (CAS 1131605-15-6)
- Imatinib Impurity 46 (CAS 1170909-72-4)
- Imatinib Impurity 91 (CAS CATO-C4X-106891)
Recommended Standards
- Revefenacin impurity 105 (CAS CATO-C4X-2031105)
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- Econazole Impurity 6 (CAS 116865-83-9)
- 4-Bromo-1-(2-chloroethyl)-3-methyl-1H-pyrazole (CAS 108354-38-7)
- Methionine Impurity 11 (CAS 33770-86-4)
- Progesterone Impurity 80 (CAS CATO-C4X-150280)
- Flurbiprofen Impurity 65 (CAS CATO-C4X-144465)
- N-((cyclohexylcarbamoyl)oxy)-2,5-bis(2,2,2-trifluoroethoxy)benzamide (CAS 338395-39-4)
- Anisyl formate (CAS 122-91-8)
- 1-Tert-butyl-5-ethyl-1h-pyrazole-4-carboxylic acid (CAS 1119459-44-7)
- N-Ethylaniline-d (CAS 844665-21-0)
- Cyclobutyl(3-methylpyridin-2-yl)methanamine (CAS 1337788-51-8)
- Methyl N-1,3-benzodioxol-5-yl-N-(methylsulfonyl)glycinate (CAS 717874-18-5)
- Neuropeptide K (human, porcine, rat) trifluoroacetate salt (CAS 96827-05-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com