Tofacitinib Impurity 55 CAS 3680-69-1
| CAS No. | 3680-69-1 |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tofacitinib Impurity 55.
Tofacitinib Impurity 55 (CAS 3680-69-1) is a certified pharmaceutical impurity reference standard with the molecular formula C6H4ClN3 and a molecular weight of 153.57 g/mol.
Tofacitinib Impurity 55 (C6H4ClN3) contains a nitrile group, chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures Tofacitinib Impurity 55 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Tofacitinib Standards
- Tofacitinib Impurity 79 (CAS 16372-08-0)
- Tofacitinib Impurity 104 (CAS 39929-79-8)
- Tofacitinib Impurity 181 (CAS CATO-C4X-1079181)
- Tofacitinib Impurity N47 (CAS 52090-68-3)
- Tofacitinib Impurity 180 (CAS 100047-45-8)
- Tofacitinib Impurity 192 (CAS CATO-C4X-1079192)
- Tofacitinib Impurity 196 (CAS CATO-C4X-1079196)
- Tofacitinib Impurity 201 (CAS CATO-C4X-1079201)
Recommended Standards
- 3320-83-0 Benzene, 1-chloro-2-isocyanato- 2-Chlorophenyl isocyanate Isocyanic acid, o-chlorophenyl ester (8CI) o-Chlorophenyl isocyanate EINECS 222-023-7 NSC 8761 EC 222-023-7 (CAS 3320-83-0)
- Roxatidine Impurity 57 (CAS 615-18-9)
- Larotrectinib Impurity 2 (CAS 29274-24-6)
- Baricitinib Impurity 31 (CAS 335654-06-3)
- Phenylephrine Impurity 19 (CAS 915278-80-7)
- Naproxen EP Impurity D (CAS 116883-62-6)
- Avibactam impurity 153 (CAS CATO-C4X-1348153)
- 5-Amino-6-(cyclohexylamino)pyrimidin-4(3H)-one (CAS 61667-18-3)
- N-methyl-1-(4-(thiophen-2-yl)tetrahydro-2H-pyran-4-yl)methanamine (CAS 916790-87-9)
- 2-Chloro-5,6-dihydro-4H-imidazo[1,5,4-de]quinoxaline (CAS 163120-51-2)
- 2-Methoxybenzaldehyde (CAS 135-02-4)
- 3-Bromo-8-ethoxyimidazo[1,2-a]pyrazine (CAS 142744-35-2)
- Melphalan DL-isomer (CAS 531-76-0)
- Semaglutide impurity 78 (CAS CATO-C4X-222678)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com