索拉非尼杂质9 CAS 370-50-3
| CAS No. | 370-50-3 |
| Molecular Formula | C15H8Cl2F6N2O |
| Molecular Weight | 417.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a process- or degradation-related impurity, 索拉非尼杂质9 (CAS 370-50-3, C15H8Cl2F6N2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
索拉非尼杂质9 (C15H8Cl2F6N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
CATO manufactures 索拉非尼杂质9 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2F6N2O |
| Molecular Weight | 417.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- Regorafenib Impurity 78 (CAS CATO-C4X-104778)
- 4-Bromo-N-(4-bromophenyl)-N-(p-tolyl)aniline (CAS 100308-67-6)
- N-(2-chloro-5-(trifluoromethyl)phenyl)-2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)acetamide (CAS 477890-21-4)
- 4-(4-Bromobenzyl)-7-oxo-2-(trifluoromethyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine-6-carboxylic acid (CAS 1135989-38-6)
- Imrecoxib Impurity 55 (CAS CATO-C4X-237955)
- Linaclotide impurity 17 (CAS 1092457-78-7)
- Ciprofloxacin EP Impurity C (CAS 103222-12-4)
- 5-(2-Bromoethyl)-1-ethyl-1h-imidazole (CAS 1466739-88-7)
- 1-chloro-2-(chloromethyl)-4-nitrobenzene (CAS 69422-57-7)
- 3-(Methylsulfonyl)-1H-pyrazolo[3,4-d]pyrimidine-4,6-diol (CAS 4927-97-3)
- 2-(3-(Hydroxymethyl)-1H-indol-1-yl)acetonitrile (CAS 675841-97-1)
- 2,5-Difluoro-3-hydroxybenzonitrile (CAS 1806367-92-9)
- 1-{2-[2-(dimethylamino)ethoxy]-6-fluorophenyl}ethan-1-ol (CAS 1354958-93-2)
- Acetyl-Tau Peptide (273-284) amide trifluoroacetate salt (CAS 1684399-52-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com