Bis(Trifluoromethyl)Aniline CAS 3700-19-4
| CAS No. | 3700-19-4 |
| Molecular Formula | C8H5F6N |
| Molecular Weight | 229.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Bis(Trifluoromethyl)Aniline (CAS 3700-19-4) is a high-purity analytical reference standard with the molecular formula C8H5F6N and a molecular weight of 229.12 g/mol.
The molecular framework of Bis(Trifluoromethyl)Aniline (C8H5F6N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H5F6N |
| Molecular Weight | 229.12 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1958 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Bis Standards
- 3,5-Bis(trifluoromethyl)aniline (CAS 328-74-5)
- 3-(Trifluoromethyl)pyridine-2-sulfonyl fluoride (CAS 1936113-73-3)
- 2-Methyl-8-(trifluoromethyl)-4H-benzo[d][1,3]oxazin-4-one (CAS 1044749-60-1)
- 3-(5-(Trifluoromethyl)-1,3,4-oxadiazol-2-yl)aniline (CAS 1197229-53-0)
- 1-(4-(Trifluoromethyl)pyrimidin-2-yl)-1H-pyrazol-4-amine (CAS 1210732-94-7)
- 4-(3-(Trifluoromethyl)-3H-diazirin-3-yl)benzamide (CAS 1216997-96-4)
- 1-[5-(trifluoromethyl)pyridin-2-yl]-1h-1,2,4-triazol-5-amine (CAS 1249569-04-7)
- 3-(4-(Trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-amine (CAS 1260886-71-2)
Recommended Standards
- 7-bromo-1H-indole-6-carbonitrile (CAS 2173193-92-3)
- Dutasteride Impurity 19 (CAS 313-13-3)
- 6-Bromo-N,N-diethyl-2-pyridinamine (CAS 856850-57-2)
- Dutasteride Impurity 20 (CAS 3822-20-6)
- Dinotefuran DN (CAS 457614-32-3)
- 3-(Phenylethynyl)isoquinoline (CAS 70437-12-6)
- 4-Cyclopropoxy-3-(methylthio)benzoic acid (CAS 1243459-33-7)
- Cloxacillin Impurity 23 (CAS CATO-C4X-159723)
- Decitabine Impurity 10 (CAS 1442660-65-2)
- (6-Ethylpyridin-2-yl)methanamine (CAS 83004-19-7)
- (2R,4S)-2,4-diaminopentanedioic acid dihydrochloride (CAS 88155-56-0)
- N-(3,4-Dimethylphenyl)-2-(1H-pyrrol-1-yl)propanamide (CAS 887029-20-1)
- tert-Butyl 2,4-dioxo-1,3,7-triazaspiro[4.4]nonane-7-carboxylate (CAS 1391738-60-5)
- Semaglutide Impurity 149 (CAS CATO-C4X-2226149)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com