Decitabine Impurity 10 CAS 1442660-65-2
| CAS No. | 1442660-65-2 |
| Molecular Formula | C15H15ClN4O5 |
| Molecular Weight | 366.76 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 366.76 g/mol gives Decitabine Impurity 10 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Decitabine Impurity 10 (CAS 1442660-65-2, C15H15ClN4O5) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Decitabine Impurity 10 is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 366.76 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H15ClN4O5 |
| Molecular Weight | 366.76 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1992 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Decitabine Standards
- Decitabine Impurity 9 (CAS CATO-C4X-11379)
- Decitabine Impurity 3 (CAS 17117-72-5)
- Decitabine Impurity 46 (CAS CATO-C4X-113746)
- Decitabine Impurity 45 (CAS CATO-C4X-113745)
- Decitabine Impurity N42 (CAS 58109-18-5)
- Decitabine Impurity 48 (CAS CATO-C4X-113748)
- Decitabine Impurity 1 (CAS 1254186-96-3)
- Decitabine Impurity 4 (CAS CATO-C4X-11374)
Recommended Standards
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- Firocoxib Impurity 2 (CAS CATO-C4X-32112)
- 1-Phenyl-3-(4-(trifluoromethyl)phenyl)prop-2-en-1-one (CAS 61637-11-4)
- 2-(4-Isopropylphenyl)quinoline-4-carboxylic acid (CAS 50733-96-5)
- 4-Oxaspiro[2.4]heptan-6-ol (CAS 1221443-32-8)
- 4-((Phenylthio)methyl)piperidine (CAS 875401-70-0)
- 4-Amino-2,3-dimethylphenol (CAS 3096-69-3)
- 2-(4-Isopropylphenoxy)acetic acid (CAS 1643-16-9)
- Des-Gln19-Tirzepatide (CAS CATO-CPTD788954)
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