2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine CAS 372122-55-9
| CAS No. | 372122-55-9 |
| Molecular Formula | C14H8F4N2 |
| Molecular Weight | 280.22 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine (CAS 372122-55-9) is a high-purity analytical reference standard with the molecular formula C14H8F4N2 and a molecular weight of 280.22 g/mol.
2-(4-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine (C14H8F4N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8F4N2 |
| Molecular Weight | 280.22 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluorophenyl Standards
- 2-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-benzo[d]imidazole (CAS 1196131-36-8)
- 2-(4-Fluorophenyl)-5-(trifluoromethyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1420885-96-6)
- 2-(3-Fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridine (CAS 372122-53-7)
- 2-{3-[(2-fluorophenyl)methyl]-2,4,5-trioxoimidazolidin-1-yl}acetic acid (CAS 303986-57-4)
- 5-(2-(4-Fluorophenyl)acetyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (CAS 1174047-11-0)
- (4-Fluorophenyl)diphenylphosphane (CAS 18437-72-4)
- 4-(4-(4-Fluorophenyl)piperazin-1-yl)-4-oxobutanoic acid (CAS 354551-55-6)
- 8-(4-Fluorophenyl)-1,4-dioxaspiro[4.5]decane-8-carboxylic acid (CAS 56327-03-8)
Recommended Standards
- 3-((2,2,3,3-Tetrafluoropropoxy)methyl)benzohydrazide (CAS 438473-63-3)
- ML318 (CAS 1610516-67-0)
- 4-((2,2,3,3-Tetrafluoropropoxy)methyl)benzohydrazide (CAS 438473-25-7)
- 4,5,6,7-Tetrafluoro-3-methyl-1-phenyl-1H-indazole (CAS 84409-38-1)
- 4-Amino-2-(methylthio)-5-pyrimidinecarboxylic Acid Ethyl Ester (CAS 776-53-4)
- 5-(p-Isopropylphenyl)-1,3-cyclohexanedione (CAS 27463-47-4)
- 2-{2-[2-(tert-Butyl)-4-methylphenoxy]-ethyl}piperidine hydrochloride (CAS 1219956-97-4)
- 4-Formyl-3-(trifluoromethoxy)benzoic acid (CAS 2168813-13-4)
- Tirasemtiv (CAS 1005491-05-3)
- 6-Acetamido-4-methylpyridine-2-sulfonyl chloride (CAS 1393547-68-6)
- 4-(1-Chloroethyl)benzoic acid (CAS 479625-84-8)
- Ethyl 4-(((((2R,3R,4S,5R,6S)-4,5-bis((benzo[d][1,3]dioxol-5-ylcarbamoyl)oxy)-2-(hydroxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)carbonyl)amino)benzoate (CAS 1137359-47-7)
- Tert-butyl 3-(piperazine-1-carbonyl)piperidine-1-carboxylate (CAS 1305712-44-0)
- Semaglutide Impurity 129 (CAS 2490269-79-7)
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