4-(Chloromethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole CAS 372190-35-7
| CAS No. | 372190-35-7 |
| Molecular Formula | C16H12ClFN2 |
| Molecular Weight | 286.73 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(Chloromethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole (C16H12ClFN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 4-(Chloromethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole (CAS 372190-35-7), a certified reference material (molecular formula C16H12ClFN2, MW 286.73 g/mol) for analytical method development and quality control.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(Chloromethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H12ClFN2 |
| Molecular Weight | 286.73 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloromethyl Standards
- Methyl 6-(chloromethyl)-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 1260621-91-7)
- Ethyl 2-(chloromethyl)-5-methyl-4-oxo-3H,4H-thieno[2,3-d]pyrimidine-6-carboxylate (CAS 89567-06-6)
- 5-(Chloromethyl)-3-(2-phenoxyphenyl)-1,2,4-oxadiazole (CAS 1956324-24-5)
- 2-((6-(Chloromethyl)pyridin-2-yl)methyl)isoindoline-1,3-dione (CAS 628308-52-1)
- 5-(Chloromethyl)-3-(3-phenoxyphenyl)-1,2,4-oxadiazole (CAS 937664-97-6)
- 2-(Chloromethyl)-2-methyl-3-phenyl-2,3-dihydroquinazolin-4(1H)-one (CAS 217461-83-1)
- 1-(Chloromethyl)-4-(4-(trifluoromethyl)phenoxy)benzene (CAS 111818-34-9)
- 1-(Chloromethyl)-2-(3-(trifluoromethyl)phenoxy)benzene (CAS 478032-57-4)
Recommended Standards
- 3-[3-(4-chloropyrimidin-5-yl)prop-2-ynyl]-1,1-dioxo-thiolan-3-ol (CAS 2605842-76-8)
- 4-Chloro-6-(thiazol-2-ylcarbamoyl)-cyclohex-3-enecarboxylic acid (CAS 332374-77-3)
- 2-Chloro-N-ethyl-N-(2-((4-fluorobenzyl)amino)-2-oxoethyl)acetamide (CAS 793679-01-3)
- 8-(2-Chloro-4-fluorophenyl)-8-oxooctanoic acid (CAS 951889-50-2)
- 2-(4-Hydroxypiperidin-1-yl)-2-phenylacetic acid hydrochloride (CAS 928322-40-1)
- 3-(Piperazin-1-yl)quinoxalin-2(1h)-one (CAS 55686-32-3)
- 6-bromo-imidazo[1,2-a]pyrimidine (CAS 865156-68-9)
- Medetomidine Impurity 30 (CAS 172498-90-7)
- 2-Chloro-N-(2,4,6-triiodophenyl)acetamide (CAS 380346-57-6)
- tert-Butyl N-(((9H-fluoren-9-yl)methoxy)carbonyl)-N-(2-oxoethyl)glycinate (CAS 330187-55-8)
- (S)-1-(tert-butoxycarbonyl)-2-oxopiperidine-4-carboxylic acid (CAS 2165829-55-8)
- 4-Amino-1-((2R,4S,5R)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one (CAS 51246-79-8)
- 2-(4-(Difluoromethoxy)phenyl)-4-methylthiazole-5-carboxylic acid (CAS 1096903-65-9)
- C-Peptide 2 (rat) (CAS 41594-08-5)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com