1-(Chloromethyl)-2-(3-(trifluoromethyl)phenoxy)benzene CAS 478032-57-4
| CAS No. | 478032-57-4 |
| Molecular Formula | C14H10ClF3O |
| Molecular Weight | 286.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 286.68 g/mol gives 1-(Chloromethyl)-2-(3-(trifluoromethyl)phenoxy)benzene distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-(Chloromethyl)-2-(3-(trifluoromethyl)phenoxy)benzene (CAS 478032-57-4), molecular formula C14H10ClF3O and molecular weight 286.68 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 1-(Chloromethyl)-2-(3-(trifluoromethyl)phenoxy)benzene (C14H10ClF3O) contains a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. The molecule exhibits a degree of unsaturation (DBE) of 8.0, corresponding to approximately 8 ring(s) or double-bond equivalent(s). With a molecular weight of 286.68 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10ClF3O |
| Molecular Weight | 286.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
Related Chloromethyl Standards
- 1-(Chloromethyl)-4-(4-(trifluoromethyl)phenoxy)benzene (CAS 111818-34-9)
- 5-(Chloromethyl)-3-(2-phenoxyphenyl)-1,2,4-oxadiazole (CAS 1956324-24-5)
- 2-((6-(Chloromethyl)pyridin-2-yl)methyl)isoindoline-1,3-dione (CAS 628308-52-1)
- 5-(Chloromethyl)-3-(3-phenoxyphenyl)-1,2,4-oxadiazole (CAS 937664-97-6)
- Methyl 6-(chloromethyl)-2-oxo-4-(thiophen-2-yl)-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 1260621-91-7)
- 4-(Chloromethyl)-3-(4-fluorophenyl)-1-phenyl-1H-pyrazole (CAS 372190-35-7)
- Ethyl 2-(chloromethyl)-5-methyl-4-oxo-3H,4H-thieno[2,3-d]pyrimidine-6-carboxylate (CAS 89567-06-6)
- 2-(Chloromethyl)-2-methyl-3-phenyl-2,3-dihydroquinazolin-4(1H)-one (CAS 217461-83-1)
Recommended Standards
- 1-(Benzyloxy)-3-chloro-5-(trifluoromethyl)benzene (CAS 2586125-88-2)
- 2-(3-(4-Chlorophenyl)-7-oxo-3,7-dihydro-6H-[1,2,3]triazolo[4,5-d]pyrimidin-6-yl)acetonitrile (CAS 872590-82-4)
- 2-(Benzyloxy)-4-chloro-1-(trifluoromethyl)benzene (CAS 1881293-32-8)
- 2-[(2-Chloro-6-fluorophenyl)methylidene]-2,3-dihydro-1H-indene-1,3-dione (CAS 883037-06-7)
- 2-methoxy-5-(methylamino)benzonitrile (CAS 1369930-35-7)
- 1,3-Dimethyl-1-((5-methylthiophen-2-yl)methyl)urea (CAS 1340684-34-5)
- N-(Thiophen-3-ylmethyl)aniline (CAS 51305-79-4)
- Eletriptan Impurity 2 (CAS CATO-C4X-18872)
- Benzyl 2-bromo-6-chlorobenzoate (CAS 1222903-19-6)
- 1-Allyl-4-phenylpiperazine (CAS 21057-43-2)
- Tert-butyl 2-chloro-4-methoxy-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate (CAS 2410119-23-0)
- (3S)-3-Methyl-1-(3,3,3-trifluoropropyl)piperazine (CAS 1449137-54-5)
- Niraparib Impurity 41 (CAS CATO-C4X-232941)
- Macrocyclic Peptide flaviviridae Viruses InhibitorDISCONTINUED (CAS 1510840-70-6)
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