Apixaban Impurity 54 CAS 37522-29-5
| CAS No. | 37522-29-5 |
| Molecular Formula | C12H15ClN2O3 |
| Molecular Weight | 270.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 270.71 g/mol gives Apixaban Impurity 54 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Apixaban Impurity 54 (CAS 37522-29-5, C12H15ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Apixaban Impurity 54 (C12H15ClN2O3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Apixaban Impurity 54 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H15ClN2O3 |
| Molecular Weight | 270.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Apixaban Standards
- Apixaban Impurity 70 (CAS 2816305-40-3)
- Apixaban Impurity 184 (CAS CATO-C4X-1088184)
- Apixaban Impurity 90 (CAS 60110-26-1)
- Apixaban Impurity 106 (CAS CATO-C4X-1088106)
- Apixaban Impurity 20 (CAS 1267610-26-3)
- Apixaban Impurity 29 (CAS CATO-C4X-108829)
- Apixaban Impurity 157 (CAS CATO-C4X-1088157)
- Apixaban Impurity 79 (CAS 2435783-75-6)
Recommended Standards
- Baclofen impurity 20 (CAS 137310-15-7)
- Azelastine EP Impurity D (CAS 53242-88-9)
- tert-Butyl 2-chloro-6-(methylcarbamoyl)isonicotinate (CAS 2137056-48-3)
- Alprazolam Impurity 5 (CAS 5220-83-7)
- Baloxavir Impurity 143 (CAS CATO-C4X-2108143)
- Methotrexate Impurity 76 (CAS CATO-C4X-115476)
- Fenfluramine Impurity 3 (CAS 713-45-1)
- 4-Bromo-1-(4-fluorobenzyl)-3-nitro-1h-pyrazole (CAS 512824-95-2)
- N-(2-hydroxyethyl)-2-(trifluoromethyl)benzenesulfonamide (CAS 1039755-99-1)
- tert-Butyl ((1-(4-chloro-6-methylpyrimidin-2-yl)piperidin-4-yl)methyl)carbamate (CAS 1261229-60-0)
- 2,4-Dimethoxythiophenol (CAS 18906-37-1)
- Ginsenoside Rb3 (CAS 68406-26-8)
- 2-Bromo-4-methyl-N-(pyrrolidin-2-ylmethyl)aniline dioxalate (CAS 1177341-32-0)
- Tau Peptide (307-321) trifluoroacetate salt (CAS 330456-50-3)
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