Baclofen impurity 20 CAS 137310-15-7
| CAS No. | 137310-15-7 |
| Molecular Formula | C13H15ClO4 |
| Molecular Weight | 270.71 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Baclofen impurity 20 (CAS 137310-15-7) is a certified pharmaceutical impurity reference standard with the molecular formula C13H15ClO4 and a molecular weight of 270.71 g/mol.
Baclofen impurity 20 (C13H15ClO4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Baclofen impurity 20 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H15ClO4 |
| Molecular Weight | 270.71 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1996 |
| Halogen Content | Cl-containing |
Related Baclofen Standards
- Baclofen Impurity 47 (CAS CATO-C4X-101247)
- Baclofen Impurity 68 (CAS CATO-C4X-101268)
- Baclofen Impurity 79 (CAS 947583-11-1)
- Baclofen impurity 45 (CAS CATO-C4X-101245)
- Baclofen Impurity 63 (CAS CATO-C4X-101263)
- Baclofen Impurity 64 (CAS CATO-C4X-101264)
- Baclofen Impurity 35 (CAS CATO-C4X-101235)
- Baclofen Impurity 39 (CAS CATO-C4X-101239)
Recommended Standards
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- Apixaban Impurity 54 (CAS 37522-29-5)
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- Azelastine EP Impurity D (CAS 53242-88-9)
- Lomustine EP Impurity B (CAS 13908-11-7)
- Mivacurium Chloride Impurity 15 (CAS 107740-66-9)
- Molnupiravir Impurity 3 (CAS 3258-02-4)
- 3,5-Bis(trifluoromethyl)benzylboronic acid (CAS 1451393-52-4)
- N,3-dimethylazetidin-3-amine (CAS 149696-11-7)
- 7-chloroimidazo[1,2-a]pyridine-2-carboxylic acid (CAS 1020038-42-9)
- 4-methanesulfonyl-5-methylfuran-2-carboxylic acid (CAS 910442-09-0)
- 2-(3-Chlorophenyl)-5-methyl-2H-1,2,3-triazol-4-amine (CAS 1708400-87-6)
- 2-Chloro-5-(((1-methyl-1h-imidazol-2-yl)thio)methyl)pyridine (CAS 821782-44-9)
- Des-Leu14-Tirzepatide (CAS CATO-CPTD788959)
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