Piperazine Impurity 1 CAS 37652-50-9
| CAS No. | 37652-50-9 |
| Molecular Formula | C17H20N2S |
| Molecular Weight | 284.42 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Based on its molecular formula C17H20N2S, Piperazine Impurity 1 contains a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 284.42 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a process- or degradation-related impurity, Piperazine Impurity 1 (CAS 37652-50-9, C17H20N2S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Piperazine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H20N2S |
| Molecular Weight | 284.42 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Piperazine Standards
- 4-(4-Methyl-piperazine-1-sulfonyl)-benzoic acid (CAS 19580-36-0)
- 4-Boc-piperazine-1-sulfonyl Chloride (CAS 162046-65-3)
- Piperazine, 1-[(2-chloro-5-nitrophenyl)methyl]-4-ethyl- (CAS 414881-87-1)
- 4-Cbz-piperazine-1-carbonyl Chloride (CAS 25539-27-9)
- 2,2'-(Piperazine-1,4-diyl)bis(2-methylpropanethioamide) (CAS 1208621-12-8)
- Piperazine-1,4-dicarbonitrile (CAS 22005-33-0)
- 1,1'-(Piperazine-1,4-diyl)bis(2,2,2-trifluoroethan-1-one) (CAS 6345-81-9)
- 3-Methyl-8-(piperazine-1-sulfonyl)quinoline (CAS 1050885-72-7)
Recommended Standards
- Chlorpromazine Impurity 8 (CAS 58-40-2)
- 4-(2-Benzothiazolyldithio)morpholine (CAS 95-32-9)
- Promethazine EP Impurity B (CAS 303-14-0)
- Muricatacin (CAS 134698-86-5)
- Rivaroxaban Impurity 102 (CAS 28025-61-8)
- Dalilesen Impurity 4 (CAS 2901043-05-6)
- Betamethasone Impurity 141 (CAS CATO-C4X-1437141)
- 4-Cyclohexyl-3-oxobutanenitrile (CAS 95882-31-8)
- rel-(1S,2R,3S,4R)-3-methoxycarbonyl-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylic acid (CAS 146339-80-2)
- 1-(2-(2-Fluorophenyl)thiazol-4-yl)ethan-1-amine (CAS 1339881-94-5)
- 2-Bromo-5-(4-nitrophenoxy)-1,3,4-thiadiazole (CAS 1343454-17-0)
- Cyclohexyl(3-methoxyphenyl)methanamine (CAS 1179863-30-9)
- Tert-butyl 3-amino-6-cyclobutyl-4,6-dihydropyrrolo[3,4-c]pyrazole-5(1H)-carboxylate (CAS 1196153-51-1)
- Semaglutide Impurity 2 (CAS CATO-C4X-22262)
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