Eltrombopag Impurity 21 CAS 376591-95-6
| CAS No. | 376591-95-6 |
| Molecular Formula | C13H9NO5 |
| Molecular Weight | 259.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Eltrombopag Impurity 21 (C13H9NO5) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies Eltrombopag Impurity 21 (CAS 376591-95-6), a pharmacopoeial impurity reference standard (molecular formula C13H9NO5, MW 259.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Eltrombopag Impurity 21 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H9NO5 |
| Molecular Weight | 259.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 113 (CAS CATO-C4X-1198113)
- Eltrombopag Impurity 114 (CAS CATO-C4X-1198114)
- Eltrombopag Impurity 115 (CAS CATO-C4X-1198115)
- Eltrombopag Impurity 122 (CAS CATO-C4X-1198122)
- Eltrombopag Impurity 127 (CAS CATO-C4X-1198127)
- Eltrombopag Impurity 89 (CAS 1097777-60-0)
- Eltrombopag Impurity 67 (CAS CATO-C4X-119867)
- Eltrombopag Impurity 116 (CAS CATO-C4X-1198116)
Recommended Standards
- Bumetanide Impurity 94 (CAS 202209-14-1)
- Vadadustat 13C6 (CAS 1000025-07-9)
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- Baloxavir Impurity 32 (CAS 2986084-03-9)
- Pregabalin Impurity N48 (CAS 35158-25-9)
- Azelnidipine Impurity 9 (CAS CATO-C4X-10409)
- 1-(6-(4-Fluorophenyl)indolizin-3-yl)-1H-pyrazole-3-carboxylic acid (CAS 1422138-42-8)
- 2,3-Dichloro-4-(trifluoromethoxy)phenol (CAS 1803826-77-8)
- N-(oxetan-3-yl)piperidin-4-amine (CAS 1349716-31-9)
- 4-Cyclopropoxy-2-formylbenzonitrile (CAS 1243446-50-5)
- 3-Cyclopropoxy-2-isopropoxy-N,N-dimethylpyridin-4-amine (CAS 1243460-33-4)
- (S)-(+)-(3,5-Dioxa-4-phosphacyclohepta[2,1-a:3,4-a']dinaphthalen-4-yl)piperidine (CAS 284472-79-3)
- Semaglutide impurity 70 (CAS CATO-C4X-222670)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com