Eltrombopag Impurity 61 CAS 376592-57-3
| CAS No. | 376592-57-3 |
| Molecular Formula | C13H9ClO3 |
| Molecular Weight | 248.66 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Eltrombopag Impurity 61 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
As a process- or degradation-related impurity, Eltrombopag Impurity 61 (CAS 376592-57-3, C13H9ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Eltrombopag Impurity 61 (C13H9ClO3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C13H9ClO3 |
| Molecular Weight | 248.66 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
Related Eltrombopag Standards
- Eltrombopag Impurity 53 (CAS CATO-C4X-119853)
- Eltrombopag Impurity 26 (CAS CATO-C4X-119826)
- Eltrombopag impurity 141 (CAS CATO-C4X-1198141)
- Eltrombopag Impurity 157 (CAS CATO-C4X-1198157)
- Eltrombopag Impurity 94 (CAS 1176777-76-6)
- Eltrombopag Impurity 95 (CAS 2230800-88-9)
- Eltrombopag Impurity 52 (CAS CATO-C4X-119852)
- Eltrombopag impurity 143 (CAS CATO-C4X-1198143)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com