Eltrombopag Impurity 8 CAS 376592-93-7
| CAS No. | 376592-93-7 |
| Molecular Formula | C13H11NO3 |
| Molecular Weight | 229.23 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Eltrombopag Impurity 8 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
As a process- or degradation-related impurity, Eltrombopag Impurity 8 (CAS 376592-93-7, C13H11NO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Eltrombopag Impurity 8 (C13H11NO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 229.23 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C13H11NO3 |
| Molecular Weight | 229.23 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Nitrogen Atoms | 1 |
Related Eltrombopag Standards
- Eltrombopag Impurity 117 (CAS CATO-C4X-1198117)
- Eltrombopag Impurity 118 (CAS CATO-C4X-1198118)
- Eltrombopag impurity 151 (CAS CATO-C4X-1198151)
- Eltrombopag Impurity 75 (CAS CATO-C4X-119875)
- Eltrombopag Impurity 92 (CAS CATO-C4X-119892)
- Eltrombopag impurity 144 (CAS CATO-C4X-1198144)
- Eltrombopag Impurity 154 (CAS CATO-C4X-1198154)
- Eltrombopag Impurity 30 (CAS 168618-47-1)
Recommended Standards
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- Lemborexant Impurity 30 (CAS CATO-C4X-304230)
- Roxatidine Impurity 41 (CAS CATO-C4X-121341)
- Dotinurad Impurity 124 (CAS 888730-55-0)
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- 5,5-Difluoropiperidin-3-one hydrochloride (CAS 1303973-33-2)
- 2-(4-(3-Fluorophenyl)-1H-pyrazol-1-yl)propanoic acid (CAS 1394023-73-4)
- 1-Methyl-3-oxo-1,2,3,4-tetrahydroquinoxaline-6-carbaldehyde (CAS 711024-26-9)
- 5,7-Dichloro-2,3-dihydro-1-benzofuran-4-amine (CAS 1353498-77-7)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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