Ticagrelor Impurity 32 CAS 376608-75-2
| CAS No. | 376608-75-2 |
| Molecular Formula | C17H24ClN5O4S |
| Molecular Weight | 429.92 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Ticagrelor Impurity 32 (CAS 376608-75-2, C17H24ClN5O4S) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Ticagrelor Impurity 32 (C17H24ClN5O4S) contains a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), Ticagrelor Impurity 32 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C17H24ClN5O4S |
| Molecular Weight | 429.92 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Ticagrelor Standards
- Ticagrelor impurity 103 (CAS CATO-C4X-1093103)
- Ticagrelor Impurity 119 (CAS CATO-C4X-1093119)
- Ticagrelor Impurity 76 (Mixture of Diastereomers) (CAS CATO-C4X-109376)
- Ticagrelor impurity 167 (CAS CATO-C4X-1093167)
- Ticagrelor Impurity 148 (CAS CATO-C4X-1093148)
- Ticagrelor Impurity 45 (CAS CATO-C4X-109345)
- Ticagrelor Impurity 47 (CAS 376608-74-1)
- Ticagrelor Impurity 52 (CAS CATO-C4X-109352)
Recommended Standards
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- 3-chloro-1,2-benzoxazole-5-sulfonyl chloride (CAS 869885-72-3)
- 1-Benzyl-5-iodo-4-phenyl-1H-1,2,3-triazole (CAS 860002-66-0)
- 5-(Pyridin-3-yl)-1-(3-(trifluoromethoxy)phenyl)-1H-1,2,3-triazole-4-carboxylic acid (CAS 1340834-14-1)
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- 1H,1H,2H,2H-PErfluoro(8,8-dimethyl-1-iodo-7-oxaoctane) (CAS 25080-24-4)
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