Ethyl (E)-3-(2-(trifluoromethyl)phenyl)acrylate CAS 376641-48-4
| CAS No. | 376641-48-4 |
| Molecular Formula | C12H11F3O2 |
| Molecular Weight | 244.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Ethyl (E)-3-(2-(trifluoromethyl)phenyl)acrylate (C12H11F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Ethyl (E)-3-(2-(trifluoromethyl)phenyl)acrylate (CAS 376641-48-4) is a high-purity analytical reference standard with the molecular formula C12H11F3O2 and a molecular weight of 244.21 g/mol.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures Ethyl (E)-3-(2-(trifluoromethyl)phenyl)acrylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H11F3O2 |
| Molecular Weight | 244.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Recommended Standards
- Cytidine-2- (CAS 478511-19-2)
- Ethyl 3-(2-(trifluoromethyl)phenyl)acrylate (CAS 50620-98-9)
- Cytidine-1- (CAS 201996-57-8)
- Methyl 2,2-difluoro-2-(3-hydroxy-1,1-dioxidotetrahydrothiophen-3-yl)acetate (CAS 2090976-39-7)
- 5-Ethyl-1-methyl-3-(3-nitrophenyl)-1H-1,2,4-triazole (CAS 1416440-36-2)
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- Semaglutide Impurity 142 (CAS CATO-C4X-2226142)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com