3-(2-Chloro-6-fluorophenyl)-7-hydroxy-2-methyl-4H-chromen-4-one CAS 377769-47-6
| CAS No. | 377769-47-6 |
| Molecular Formula | C16H10ClFO3 |
| Molecular Weight | 304.70 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 3-(2-Chloro-6-fluorophenyl)-7-hydroxy-2-methyl-4H-chromen-4-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies 3-(2-Chloro-6-fluorophenyl)-7-hydroxy-2-methyl-4H-chromen-4-one (CAS 377769-47-6), a certified reference material (molecular formula C16H10ClFO3, MW 304.70 g/mol) for analytical method development and quality control.
The molecular framework of 3-(2-Chloro-6-fluorophenyl)-7-hydroxy-2-methyl-4H-chromen-4-one (C16H10ClFO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C16H10ClFO3 |
| Molecular Weight | 304.70 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
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Recommended Standards
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- (1E,4E)-1-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(dimethylamino)penta-1,4-dien-3-one (CAS 303997-44-6)
- 2-tert-Butyl-1,4-benzoquinone (CAS 3602-55-9)
- 1,4-Bis(4-nitrophenoxy)butane (CAS 14467-68-6)
- (3-(1-((Tert-butoxycarbonyl)amino)-3-methylbutyl)oxetan-3-yl)glycine (CAS 2199282-78-3)
- 3-(2-Bromo-4-isopropylphenoxy)piperidinehydrochloride (CAS 1220019-15-7)
- tert-Butyl-(S)-2-(azidomethyl)-1-pyrrolidine carboxylate (CAS 2587-46-4)
- tert-Butyl (trans-4-amino-3-hydroxypiperidine-1-carboxylate (CAS 443955-98-4)
- 4-(1-Aminocyclopropyl)benzonitrile Hydrochloride (CAS 1369512-65-1)
- 2-Bromo-1-(4-(trifluoromethyl)phenyl)ethanol (CAS 32687-39-1)
- 2-(5-Methyl-1,3,4-oxadiazol-2-yl)-1h-indole (CAS 37574-80-4)
- Endo-[Glu]31-Liraglutide (CAS CATO-C4X-199234)
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