Dimethyl difluoromalonate CAS 379-95-3
| CAS No. | 379-95-3 |
| Molecular Formula | C5H6F2O4 |
| Molecular Weight | 168.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Dimethyl difluoromalonate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Dimethyl difluoromalonate (CAS 379-95-3), molecular formula C5H6F2O4 and molecular weight 168.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Dimethyl difluoromalonate (C5H6F2O4) is characterized by a carbohydrate-derived structure, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C5H6F2O4 |
| Molecular Weight | 168.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
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Recommended Standards
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- Methyl 2,3,4,6-tetrafluorobenzoate (CAS 53001-68-6)
- 2-((4-Methyl-6-phenylpyrimidin-2-yl)thio)acetic acid (CAS 77517-13-6)
- 4-(6-Chloro-2-phenylpyrimidin-4-yl)morpholine (CAS 343373-72-8)
- 3-(3-Ethoxy-4-methoxyphenyl)prop-2-en-1-ol (CAS 1563743-10-1)
- Tert-butyl indoline-2-carboxylate (CAS 1218501-71-3)
- (2S,4S)-tert-Butyl 4-((tert-butoxycarbonyl)amino)-2-(hydroxymethyl)pyrrolidine-1-carboxylate (CAS 1071062-87-7)
- 6-Chloro-5-fluoro-2-methylpyrimidin-4-amine (CAS 943006-45-9)
- 1,2-Bis[(2S,5S)-2,5-dimethyl-1-phospholanyl]ethane (CAS 136779-26-5)
- Semaglutide impurity 01 (CAS 1998701-31-7)
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