N-((2-Chloro-5-(N-(3-chlorophenyl)sulfamoyl)phenyl)carbamothioyl)-4-fluorobenzamide CAS 379712-59-1
| CAS No. | 379712-59-1 |
| Molecular Formula | C20H14Cl2FN3O3S2 |
| Molecular Weight | 498.38 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-((2-Chloro-5-(N-(3-chlorophenyl)sulfamoyl)phenyl)carbamothioyl)-4-fluorobenzamide.
N-((2-Chloro-5-(N-(3-chlorophenyl)sulfamoyl)phenyl)carbamothioyl)-4-fluorobenzamide (CAS 379712-59-1), molecular formula C20H14Cl2FN3O3S2 and molecular weight 498.38 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-((2-Chloro-5-(N-(3-chlorophenyl)sulfamoyl)phenyl)carbamothioyl)-4-fluorobenzamide (C20H14Cl2FN3O3S2) is characterized by a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C20H14Cl2FN3O3S2 |
| Molecular Weight | 498.38 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 2 |
Related N Standards
- n-(2-((2-Chloro-5-(n-(4-chlorophenyl)sulfamoyl)phenyl)amino)-2-oxoethyl)-5-methylthiophene-2-carboxamide (CAS 854358-28-4)
- N-(3-chloro-4-methylphenyl)-2-((5-(((4-chlorophenyl)amino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetamide (CAS 338430-29-8)
- 6-Chloro-1-(2-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)amino)ethyl)-3-((furan-2-ylmethyl)amino)quinoxalin-2(1H)-one (CAS 303986-19-8)
- 3,3'-((2,2-Bis((3-chloro-3-oxopropoxy)methyl)propane-1,3-diyl)bis(oxy))dipropionyl chloride (CAS 132491-88-4)
- 2-(1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-1H-indol-3-yl)-N-(2,4-dichlorophenyl)acetamide (CAS 477845-11-7)
- 2-Chloro-N-[2,2,2-trifluoro-1-[(6-nitro-2-benzothiazolyl)amino]-1-(trifluoromethyl)ethyl]benzamide (CAS 489414-77-9)
- 1-(4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazin-1-yl)-2-(4-(4-methoxyphenyl)piperazin-1-yl)ethan-1-one (CAS 338979-18-3)
- 1-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}benzenesulfonyl)-4-phenylpiperazine (CAS 344277-92-5)
Recommended Standards
- 2-((3,4-Dichlorophenyl)amino)-2-oxoethyl 6-((1,1-dioxidobenzo[d]isothiazol-3-yl)amino)hexanoate (CAS 736955-23-0)
- Platinum,(1,2-cyclohexanediamine-N,N')[[(methoxyacetyl)amino]propanedioato(2-)-O1,O3]-,[SP-4-2-(1R-trans)]- (CAS 118105-86-5)
- 2-((4-(4-Bromophenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(3-fluoro-4-methylphenyl)acetamide (CAS 477329-74-1)
- 4-(2,6-Dinitro-4-(trifluoromethyl)phenoxy)-N-(pyridin-2-ylmethyl)benzenesulfonamide (CAS 338962-20-2)
- (1-Cyclopentyl-1h-1,2,3-triazol-4-yl)methanamine (CAS 1249780-65-1)
- 3,7-Dibutyl-8-(chloromethyl)-3,7-dihydro-1h-purine-2,6-dione (CAS 848658-86-6)
- N-(5-(sec-Butylthio)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide (CAS 391875-45-9)
- 2-cyclopropylpropanenitrile (CAS 1096868-18-6)
- 2-(4-Hydroxyphenyl)-2-(4-methylpiperazin-1-yl)acetonitrile (CAS 877825-73-5)
- Selenopheno[3,2-b]selenophene (CAS 251-49-0)
- 1-((2-Bromoethyl)sulfonyl)-4-methylbenzene (CAS 5755-76-0)
- 4-Nitroisoquinolin-1-amine (CAS 78886-54-1)
- Methyl(3r)-1-[(2,4-dimethoxyphenyl)methyl]-5-oxo-pyrrolidine-3-carboxylate (CAS 1629681-81-7)
- Semaglutide impurity 88 (CAS CATO-C4X-222688)
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