(2Z)-3-[2-(Difluoromethoxy)phenyl]-2-phenylprop-2-enoic acid CAS 380344-74-1
| CAS No. | 380344-74-1 |
| Molecular Formula | C16H12F2O3 |
| Molecular Weight | 290.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (2Z)-3-[2-(Difluoromethoxy)phenyl]-2-phenylprop-2-enoic acid.
(2Z)-3-[2-(Difluoromethoxy)phenyl]-2-phenylprop-2-enoic acid (CAS 380344-74-1) is a high-purity analytical reference standard with the molecular formula C16H12F2O3 and a molecular weight of 290.26 g/mol.
(2Z)-3-[2-(Difluoromethoxy)phenyl]-2-phenylprop-2-enoic acid (C16H12F2O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, a polycyclic aromatic system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), (2Z)-3-[2-(Difluoromethoxy)phenyl]-2-phenylprop-2-enoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C16H12F2O3 |
| Molecular Weight | 290.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
Related Z Standards
- 2-(4-(Difluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one (CAS 453525-58-1)
- 2-(Difluoromethoxy)-3-(pyridin-3-yl)-6-(trifluoromethyl)pyridine (CAS 1214326-39-2)
- 6-(Difluoromethoxy)-3-(pyridin-3-yl)-2-(trifluoromethyl)pyridine (CAS 1214330-58-1)
- 2-(Difluoromethoxy)-3-(pyridin-4-yl)-5-(trifluoromethyl)pyridine (CAS 1214343-66-4)
- 2-(Difluoromethoxy)-3-(pyridin-4-yl)-6-(trifluoromethyl)pyridine (CAS 1214359-36-0)
- 6-(Difluoromethoxy)-3-(pyridin-4-yl)-2-(trifluoromethyl)pyridine (CAS 1214361-82-6)
- N-(4-(Difluoromethoxy)phenyl)-3-phenylacrylamide (CAS 305373-25-5)
- 2-Difluoromethoxy-3-phenyl-5-(trifluoromethyl)pyridine (CAS 1214368-87-2)
Recommended Standards
- rac-2,2,2-trifluoro-N-[(3R,4S)-4-(4-fluorophenyl)piperidin-3-yl]acetamide (CAS 1969288-57-0)
- (4-(1,3-Dioxolan-2-yl)phenyl)(3,5-difluorophenyl)methanone (CAS 898760-80-0)
- (2-Fluoro-4-hydrazinylphenyl)di(1H-1,2,4-triazol-1-yl)methanol (CAS 1956367-20-6)
- (4S,7R)-1-(2,4-Difluorophenyl)-4,5,6,7-tetrahydro-1H-4,7-methanoindazole-3-carboxylic acid (CAS 916591-88-3)
- 9,9-Dimethyl-6-(2-nitrophenyl)-5,6,8,9,10,11-hexahydro-7H-dibenzo[b,e][1,4]diazepin-7-one (CAS 82408-12-6)
- Allopurinol Riboside (CAS 16220-07-8)
- 3-(4-Methoxyphenyl)azetidine Hydrochloride (CAS 7606-35-1)
- 2-(Methyl(pyrazin-2-ylmethyl)amino)acetic acid (CAS 1353969-79-5)
- 1-(2,6-Dichlorobenzyl)piperidin-3-amine hydrochloride (CAS 1289388-05-1)
- Methyl 4-amino-3-(ethylamino)benzoate (CAS 1242268-09-2)
- Fmoc-DL-Ala-OH (CAS 35661-38-2)
- 3-(4-Bromothiophen-2-yl)-N-methylpropanamide (CAS 1424309-67-0)
- 2-Bromo-N-(4-(methylthio)-1-(2-(2-morpholinothiazole-4-carbonyl)hydrazinyl)-1-oxobutan-2-yl)benzamide (CAS 1139885-23-6)
- Peptide 6A (H-6905.0005) (CAS 73549-32-3)
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