2-(4-(Difluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one CAS 453525-58-1
| CAS No. | 453525-58-1 |
| Molecular Formula | C15H12F2N2O2 |
| Molecular Weight | 290.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(4-(Difluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one (CAS 453525-58-1), molecular formula C15H12F2N2O2 and molecular weight 290.26 g/mol, is a CATO reference standard with documented purity and traceability.
2-(4-(Difluoromethoxy)phenyl)-2,3-dihydroquinazolin-4(1H)-one (C15H12F2N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C15H12F2N2O2 |
| Molecular Weight | 290.26 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Difluoromethoxy Standards
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Recommended Standards
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- (E)-2-((benzyloxy)imino)-N-(2,4-difluorophenyl)acetamide (CAS 866043-49-4)
- 3,4-Difluoro-3-(1,3-dioxolan-2-yl)benzophenone (CAS 898759-65-4)
- 2-((2,5-Dimethylphenyl)carbamoyl)cyclohexane-1-carboxylic acid (CAS 296246-15-6)
- 4-(Difluoromethylsulfonyl)benzoic acid (CAS 4837-22-3)
- tert-Butyl 3-(5-bromo-N-methylthiophene-2-sulfonamido)piperidine-1-carboxylate (CAS 1261235-99-7)
- n-(2-Ethylhexyl)tetrahydro-2h-pyran-4-amine (CAS 1157011-80-7)
- 2-amino-1-(2-ethoxyphenyl)ethanol (CAS 926270-00-0)
- 3,4-Dimethoxybenzoic anhydride (CAS 24824-54-2)
- Tetrazine-PEG4-amine (hydrochloride) (CAS 2752945-36-9)
- (2R,3R,4S,5R,6R)-2-(acetoxymethyl)-6-(((2R,3R,4S,5R,6R)-4,5-diacetoxy-2-(acetoxymethyl)-6-methoxytetrahydro-2H-pyran-3-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl triacetate (CAS 13223-83-1)
- 1-(3-Fluorophenyl)-3-methylcyclopentan-1-ol (CAS 1339615-26-7)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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