5-[3-(morpholine-4-sulfonyl)phenyl]-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazole-3-thiol CAS 380436-79-3
| CAS No. | 380436-79-3 |
| Molecular Formula | C19H17F3N4O3S2 |
| Molecular Weight | 470.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution, 5-[3-(morpholine-4-sulfonyl)phenyl]-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazole-3-thiol is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 470.49 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 5-[3-(morpholine-4-sulfonyl)phenyl]-4-[3-(trifluoromethyl)phenyl]-4H-1,2,4-triazole-3-thiol (CAS 380436-79-3), a certified reference material (molecular formula C19H17F3N4O3S2, MW 470.49 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C19H17F3N4O3S2 |
| Molecular Weight | 470.49 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
| Sulfur Atoms | 2 |
Related morpholine Standards
- Morpholine Impurity 8 (CAS CATO-C4X-31688)
- 13-(4-(Morpholine-4-carbonyl)phenyl)-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-dione (CAS 956791-09-6)
- 5-[3-(Morpholine-4-sulfonyl)-phenyl]-4-(4-trifluoromethoxy-phenyl)-4H-[1,2,4]triazole-3-thiol (CAS 519151-94-1)
- 7-(Morpholine-4-sulfonyl)-5-{[3-(trifluoromethyl)phenyl]methyl}-1H,2H,3H,3aH,4H,5H-pyrrolo[1,2-a]quinoxalin-4-one (CAS 1042134-64-4)
- 2-Methyl-5-(morpholine-4-sulfonyl)-n-[4-(pyridin-4-yl)-1,3-thiazol-2-yl]benzamide (CAS 869633-94-3)
- 4-Methyl-3-(morpholine-4-sulfonyl)-n-[4-(pyridin-2-yl)-1,3-thiazol-2-yl]benzamide (CAS 848373-17-1)
- 5-[3-(Morpholine-4-sulfonyl)phenyl]-4-(2,4,4-trimethylpentan-2-yl)-4H-1,2,4-triazole-3-thiol (CAS 522606-46-8)
- Morpholine Impurity 6 (CAS CATO-C4X-31686)
Recommended Standards
- 4-(3-Fluoro-4-methoxybenzoyl)-3-hydroxy-5-(3-hydroxyphenyl)-1-(3-morpholinopropyl)-1H-pyrrol-2(5H)-one (CAS 618073-00-0)
- β-Estradiol 17-(β-D-glucuronide) sodium salt (CAS CATO-C3D-1941)
- Ethyl 2-amino-3-(4-(5-(4-((tert-butoxycarbonyl)amino)phenyl)-1,2,4-oxadiazol-3-yl)-3-fluorophenyl)propanoate (CAS 1323994-78-0)
- Paliperidone Impurity 16 (CAS 1006685-69-3)
- 3-Amino-4H-thieno[3,4-c]chromen-4-one (CAS 41078-15-3)
- 4-Nitrophenyl β-D-xylotrioside (CAS 173468-29-6)
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- (3-Fluoropyridin-4-yl)methanamine dihydrochloride (CAS 1257535-26-4)
- 3-Bromo-1-chloro-5,5-dimethylhydantoin (CAS 126-06-7)
- (5-(1,1-Difluoroethyl)pyridin-3-yl)methanamine (CAS 1211532-07-8)
- 5-[Benzyl-(4-chloro-phenyl)-sulfamoyl]-2-chloro-benzoic acid (CAS 735322-07-3)
- 10α-Hydroxy-nalfurafine (CAS 1054312-75-2)
- tert-Butyl 2-(4-bromo-3-fluorophenyl)morpholine-4-carboxylate (CAS 1400997-38-7)
- Liraglutide (CAS 204656-20-2)
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