Loratadine Impurity 14 CAS 38089-93-9
| CAS No. | 38089-93-9 |
| Molecular Formula | C20H23ClN2O |
| Molecular Weight | 342.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Loratadine Impurity 14 (C20H23ClN2O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Loratadine Impurity 14 (CAS 38089-93-9, C20H23ClN2O) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Loratadine Impurity 14 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H23ClN2O |
| Molecular Weight | 342.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1967 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 27 (CAS 130642-50-1)
- Loratadine Impurity 91 (CAS CATO-C4X-142691)
- Loratadine Impurity 29 (CAS 125743-81-9)
- Loratadine Impurity 98 (CAS CATO-C4X-142698)
- Loratadine Impurity 99 (CAS CATO-C4X-142699)
- Loratadine Impurity 101 (CAS CATO-C4X-1426101)
- Loratadine Impurity 2 (CAS 96034-64-9)
- Loratadine Impurity 77 (CAS 170727-68-1)
Recommended Standards
- Metoclopramide Impurity 113 (CAS CATO-C4X-1415113)
- 1'-Benzyl-7-chloro-4,5-dihydro-3H-spiro[benzo[b][1,4]oxazepine-2,4'-piperidine] (CAS 947617-95-0)
- Desloratadine Impurity 34 (CAS CATO-C4X-143034)
- 1-(Benzenesulfonyl)-3-[(4-chlorophenyl)sulfanyl]propan-2-ol (CAS 338409-57-7)
- Levetiracetam Impurity 5 (CAS 358629-51-3)
- Atomoxetine Impurity 50 (CAS 1007832-68-9)
- Relugolix Impurity 58 (CAS CATO-C4X-242958)
- 1-(3-Bromo-benzyl)-4-ethoxy-1H-pyrazole (CAS 1869783-70-9)
- (R)-2-(methyl(pyrrolidin-3-yl)amino)ethan-1-ol (CAS 917357-86-9)
- Lactulose Impurity N1 (CAS 41847-61-4)
- 4-hydroxypyrrolo[2,1-f][1,2,4]triazine-7-carboxylic acid (CAS 1781902-17-7)
- 3-Chloro-5-ethoxyaniline (CAS 1312139-62-0)
- 2-EThoxy-7-nitro-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid ethyl ester (CAS 83842-10-8)
- Neuropeptide Y (1-24) amide (human, rat) (CAS 131448-51-6)
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