Loratadine Impurity 77 CAS 170727-68-1
| CAS No. | 170727-68-1 |
| Molecular Formula | C20H23ClN2 |
| Molecular Weight | 326.86 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures Loratadine Impurity 77 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
CATO supplies Loratadine Impurity 77 (CAS 170727-68-1), a pharmacopoeial impurity reference standard (molecular formula C20H23ClN2, MW 326.86 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Loratadine Impurity 77 (C20H23ClN2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 10.0, corresponding to approximately 10 ring(s) or double-bond equivalent(s). With a molecular weight of 326.86 g/mol, it falls into the moderately-high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H23ClN2 |
| Molecular Weight | 326.86 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 94 (CAS CATO-C4X-142694)
- Loratadine Impurity 30 (CAS 1346600-30-3)
- Loratadine EP Impurity G (CAS 38092-89-6)
- Loratadine Impurity 53 (CAS 107285-30-3)
- Loratadine Impurity 98 (CAS CATO-C4X-142698)
- Loratadine Impurity 99 (CAS CATO-C4X-142699)
- Loratadine Impurity 76 (CAS CATO-C4X-142676)
- Loratadine Impurity 91 (CAS CATO-C4X-142691)
Recommended Standards
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- Mecoprop-2-Ethylhexyl Ester (CAS 71526-69-7)
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- 4-Ethoxy-N-phenylpyrimidin-2-amine (CAS 110235-37-5)
- Acetyl tetrapeptide-9(Dermican LS 9837) (CAS 928006-50-2)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com