Difluoroacetyl Chloride CAS 381-72-6
| CAS No. | 381-72-6 |
| Molecular Formula | C2HClF2O |
| Molecular Weight | 114.48 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Difluoroacetyl Chloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Difluoroacetyl Chloride (CAS 381-72-6), molecular formula C2HClF2O and molecular weight 114.48 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of Difluoroacetyl Chloride (C2HClF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C2HClF2O |
| Molecular Weight | 114.48 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
Related Difluoroacetyl Standards
- 2-(Difluoroacetyl)pyridine (CAS 80459-00-3)
- 2-(2,2-Difluoroacetyl)cyclopentan-1-one (CAS 938001-14-0)
- 2-(2,2-difluoroacetyl)bicyclo[3.1.0]hexan-3-one (CAS 1626337-81-2)
- 2-(2,2-Difluoroacetyl)cyclohexanone (CAS 149894-28-0)
- (+)-3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (CAS 183279-72-3)
- 3-(2,2-Difluoroacetyl)tetrahydro-2H-pyran-2-one (CAS 606491-81-0)
- 4-(2,2-Difluoroacetyl)benzonitrile (CAS 1176519-89-3)
- N-(2,2-Difluoroacetyl)-2,2-difluoroacetohydrazide (CAS 155093-22-4)
Recommended Standards
- 2414-98-4 O81SA5A7L6 Magnesium diethanolate Magnesium ethanolate Ethanol, magnesium salt (2:1) Ethanol, magnesium salt EINECS 219-323-5 Magnesium ethoxide Magnesium ethylate UNII-O81SA5A7L6 EC 219-323-5 (CAS 2414-98-4)
- 2,2-Difluoropropyl Chloride (CAS 420-99-5)
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