4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2h-pyrrol-2-one CAS 381702-30-3
| CAS No. | 381702-30-3 |
| Molecular Formula | C22H17FN2O4S |
| Molecular Weight | 424.44 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2h-pyrrol-2-one.
4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2h-pyrrol-2-one (CAS 381702-30-3) is a high-purity analytical reference standard with the molecular formula C22H17FN2O4S and a molecular weight of 424.44 g/mol.
The molecular framework of 4-(4-Ethoxybenzoyl)-5-(4-fluorophenyl)-3-hydroxy-1-(thiazol-2-yl)-1,5-dihydro-2h-pyrrol-2-one (C22H17FN2O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H17FN2O4S |
| Molecular Weight | 424.44 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ethoxybenzoyl Standards
- 8-Benzyl-4-(2-ethoxybenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326811-20-4)
- 4-(4-Ethoxybenzoyl)-5-(2-fluorophenyl)-3-hydroxy-1-((tetrahydrofuran-2-yl)methyl)-1H-pyrrol-2(5H)-one (CAS 618073-46-4)
- 1-(4-Ethoxybenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775402-54-4)
- 1-(4-Ethoxybenzoyl)-4-{[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775493-45-2)
- 1-(2-Ethoxybenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775517-65-1)
- 4-(4-Ethoxybenzoyl)-5-(2-fluorophenyl)-1-(furan-2-ylmethyl)-3-hydroxy-1H-pyrrol-2(5H)-one (CAS 618073-45-3)
- 3-[1-(4-Ethoxybenzoyl)piperidin-4-yl]-4-[(4-methoxyphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775297-56-7)
- 5-(4-(4-Ethoxybenzoyl)piperazin-1-yl)-2-(thiophen-2-yl)oxazole-4-carbonitrile (CAS 946200-76-6)
Recommended Standards
- (R)-2-(6-(tert-butoxycarbonyl)-8-(3,5-difluorophenyl)-10-oxo-6,9-diazaspiro[4.5]decan-9-yl)acetic acid (CAS 957187-37-0)
- 5-(Tert-butyl) 1-(4-nitrophenyl) (tert-butoxycarbonyl)-D-glutamate (CAS 200397-60-0)
- (E)-N-(4-(2-(benzo[d]thiazol-2-yl)vinyl)phenyl)-3-(trifluoromethyl)benzamide (CAS 478049-97-7)
- Amicoumacin B (CAS 77674-99-8)
- Tert-butyl (1-benzyl-2,4,6-trimethylpiperidin-3-yl)carbamate (CAS 1315365-74-2)
- Tert-butyl (S)-3-hydroxybutanoate (CAS 82578-45-8)
- 3,5-Difluoro-4-(methyl)thiophenol (CAS 1804515-76-1)
- 2-Chloro-3-(1H-pyrazol-1-yl)pyrazine (CAS 1209459-17-5)
- 2-(Aminomethyl)-3-(difluoromethyl)-5-fluoropyridine-6-acetic acid (CAS 1805479-38-2)
- 3-Methyl-N-propyl-3h-[1,2,3]triazolo[4,5-d]pyrimidin-7-amine (CAS 899757-45-0)
- Naled-d (CAS 1216605-57-0)
- 6-Nitro-1,2,3,4-tetrahydroisoquinoline (CAS 186390-77-2)
- (E)-2-methoxy-4-(3-oxoprop-1-enyl)phenyl acetate 4-Acetoxy-3-methoxycinnamaldehyde 83071-67-4 (CAS 83071-67-4)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
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