2-(5-Bromo-2-chlorophenyl)pyrrolidine CAS 383127-78-4
| CAS No. | 383127-78-4 |
| Molecular Formula | C10H11BrClN |
| Molecular Weight | 260.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(5-Bromo-2-chlorophenyl)pyrrolidine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(5-Bromo-2-chlorophenyl)pyrrolidine (CAS 383127-78-4), molecular formula C10H11BrClN and molecular weight 260.56 g/mol, is a CATO reference standard with documented purity and traceability.
2-(5-Bromo-2-chlorophenyl)pyrrolidine (C10H11BrClN) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine/bromine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(5-Bromo-2-chlorophenyl)pyrrolidine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H11BrClN |
| Molecular Weight | 260.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2025 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-(4-Bromo-2-chlorophenyl)pyrrolidine (CAS 1157719-55-5)
- n-(4-Bromo-2-chlorobenzyl)cyclopropanamine (CAS 1157720-31-4)
- 2-Bromo-N-(4-chlorobenzyl)prop-2-en-1-amine (CAS 1178438-59-9)
- (S)-(4-bromo-3-chlorophenyl)(cyclopropyl)methanamine (CAS 1213389-76-4)
- (S)-2-(4-bromo-3-chlorophenyl)pyrrolidine (CAS 1213861-78-9)
- (R)-2-(4-bromo-3-chlorophenyl)pyrrolidine (CAS 1213921-31-3)
- (R)-2-(4-bromo-2-chlorophenyl)pyrrolidine (CAS 1228558-91-5)
- (S)-2-(2-Bromo-4-chlorophenyl)pyrrolidine (CAS 1228561-50-9)
Recommended Standards
- N-[(2-Bromo-6-chlorophenyl)methyl]cyclopropanamine (CAS 1862736-22-8)
- N-(5-Bromo-2-chlorobenzyl)cyclopropanamine (CAS 945999-91-7)
- 1,1,1,3,3-Pentamethyl-3-octyldisiloxane (CAS 180006-15-9)
- 1,2-Bis-(tert-butyldimethylsilyl)hydrazine (CAS 10000-20-1)
- 1-[3-bromo-5-(trifluoromethyl)phenyl]hexahydropyrimidine-2,4-dione (CAS 1532639-55-6)
- 1-Phenylquinolin-4(1H)-one (CAS 40695-01-0)
- 1-(4-Bromobenzyl)-1H-pyrazole (CAS 1159826-63-7)
- 6-Amino-2-thiaspiro[3.3]heptane 2,2-dioxide hydrochloride (CAS 2137836-62-3)
- 3-((Dimethylamino)methyl)-1H-indole-4-carboxylic acid (CAS 104510-18-1)
- 3-Fluorophenmetrazine Hydrochloride (CAS 1803562-83-5)
- Dapagliflozin Impurity 89 (CAS CATO-C4X-113889)
- (2R)-2-(1,3-Dioxoisoindol-2-yl)-4-methylpentanoic acid (CAS 29588-87-2)
- 2-chloro-N4-(3-oxa-8-azabicyclo[3.2.1]octan-8-yl)pyrimidine-4,5-diamine (CAS 2646592-48-3)
- Semaglutide impurity 250 (CAS CATO-C4X-2226250)
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